TIE1 and TEK

Number of citations of the paper that reports this interaction (PMID 10995770)
13

Data Source:
HPRD (in vivo)

		TIE1	TEK
Gene Name		tyrosine kinase with immunoglobulin-like and EGF-like domains 1	TEK tyrosine kinase, endothelial
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Stress Fiber Extracellular Region Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Junction Focal Adhesion Basal Plasma Membrane Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Activity Protein Binding ATP Binding Growth Factor Binding
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Signal Transduction Mesoderm Development Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell Migration Response To Retinoic Acid Plasma Membrane Fusion	Angiogenesis Response To Hypoxia Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Endochondral Ossification Sprouting Angiogenesis Positive Regulation Of Cytokine Secretion Involved In Immune Response Cell-matrix Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Heart Development Blood Coagulation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Single Organismal Cell-cell Adhesion Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Organ Regeneration Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Peptidyl-serine Phosphorylation Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Angiogenesis Protein Autophosphorylation Tie Signaling Pathway Negative Regulation Of Inflammatory Response Leukocyte Migration Protein Oligomerization Response To CAMP Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Definitive Hemopoiesis Heart Trabecula Formation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Actin Cytoskeleton Reorganization Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways			Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ANGPT4 KRT40 MDFI PIK3R1 PSG5 PTPN11 RBPMS TEK	20 interactors: ANGPT1 ANGPT2 ANGPT4 ANGPTL1 APP DOK2 DOK4 GRB14 GRB2 GRB7 IKBKG PIK3R1 PTPN11 PTPRB SHC1 SOCS1 STAT5A STAT5B TIE1 TNIP2
Entrez ID		7075	7010
HPRD ID		02572	02571
Ensembl ID		ENSG00000066056	ENSG00000120156
Uniprot IDs		B4DTW8 P35590	Q02763 Q59HG2
PDB IDs			1FVR 2GY5 2GY7 2OO8 2OSC 2P4I 2WQB 3BEA 3L8P 4K0V
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Regulation Of Intracellular Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Regulation Of Phosphorylation Regulation Of Protein Transport Leukocyte Migration Regulation Of Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Localization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Import Into Nucleus Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Positive Regulation Of Transport Regulation Of Signaling Positive Regulation Of Intracellular Transport Activation Of Protein Kinase Activity Cell Migration Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Glucose Import Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cell Migration Positive Regulation Of Glucose Transport Positive Regulation Of Cell Motility Positive Regulation Of Protein Transport Positive Regulation Of Cellular Component Movement	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Body Fluid Levels Enzyme Linked Receptor Protein Signaling Pathway Leukocyte Migration Blood Coagulation Hemostasis Immune System Process Signal Transduction Wound Healing Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Wounding Cellular Response To Stimulus Cell Migration Regulation Of Immune Response Response To Stimulus Cell Motility Locomotion Response To Stress Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Cellular Response To Peptide Movement Of Cell Or Subcellular Component Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Signal Transduction Response To Growth Hormone Regulation Of Innate Immune Response Intracellular Signal Transduction Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signaling Regulation Of Kinase Activity Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Angiogenesis ERBB Signaling Pathway Cellular Response To Hormone Stimulus Regulation Of Phosphorylation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Development Of Secondary Male Sexual Characteristics JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway
Tagcloud ?		algorithm bioinformatics breastmark combines commercially complements datasets dx eliminating epha5 fgfr1 fgfr3 friendly inform integrates mammaprint mirna oncotype pdgfrbeta platforms powerful reductionist robustness superfluous tailor transcriptomic user vegfr1 web	amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk
Tagcloud (Difference) ?		algorithm bioinformatics breastmark combines commercially complements datasets dx eliminating epha5 fgfr1 fgfr3 friendly inform integrates mammaprint mirna oncotype pdgfrbeta platforms powerful reductionist robustness superfluous tailor transcriptomic user vegfr1 web	amplify blk bpk cdnas cmet degenerate eck f1 fer fes fgr flk fyn hck kit lacked lin ly6a ptks rtk rtks ryk sca sixteen sorted sorter stk turned tyk
Tagcloud (Intersection) ?