TIE1 and ANGPT4

Number of citations of the paper that reports this interaction (PubMedID 10051567)
18

Data Source:
BioGRID (pull down)

		TIE1	ANGPT4
Description		tyrosine kinase with immunoglobulin like and EGF like domains 1	angiopoietin 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Mesoderm Development Tissue Development Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Response To Retinoic Acid Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly	Angiogenesis Endothelial Cell Proliferation Signal Transduction Notch Signaling Pathway Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Hypoxia
Pathways			Tie2 Signaling
Drugs		Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Food allergy ( 29030101) Intracranial aneurysm ( 29531279) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321) Lung function ( 31902109) Peanut allergy ( 29030101)
Interacting Genes		13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1	3 interacting genes: RHOU TEK TIE1
Entrez ID		7075	51378
HPRD ID		02572	04747
Ensembl ID		ENSG00000066056	ENSG00000101280
Uniprot IDs		B4DTW8 P35590	Q9Y264
PDB IDs		5N06
Enriched GO Terms of Interacting Partners?		Glomerulus Vasculature Development Tie Signaling Pathway Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Glycerolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Endothelial Cell Migration Phosphatidylinositol Metabolic Process Insulin Receptor Binding Regulation Of Intracellular Protein Transport Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Tumor Necrosis Factor Production Cell Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Hemopoiesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-substrate Adhesion Positive Regulation Of D-glucose Import Glycerophospholipid Biosynthetic Process Endothelial Cell Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phospholipid Biosynthetic Process Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Cell Migration Regulation Of Vascular Permeability Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Motility Phosphatidylinositol Phosphate Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Locomotion Vasculature Development Glycerophospholipid Metabolic Process Regulation Of D-glucose Import Regulation Of Endothelial Cell Apoptotic Process Vascular Process In Circulatory System Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade	Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Cell-substrate Junction Organization Blood Vessel Development Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Protein Tyrosine Kinase Activity Regulation Of Endothelial Cell Proliferation Branching Involved In Lymph Vessel Morphogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Receptor Complex Tie Signaling Pathway Nucleotide Binding Regulation Of Angiogenesis Glomerulus Vasculature Development Regulation Of Small GTPase Mediated Signal Transduction Angiogenesis Regulation Of Vasculature Development Lymphatic Endothelial Cell Differentiation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Disassembly Anchoring Junction Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Trabecula Formation Protein Kinase Activity Regulation Of Developmental Process Definitive Hemopoiesis Regulation Of Cellular Component Organization Positive Regulation Of Rac Protein Signal Transduction Plasma Membrane Fusion Kinase Activity Regulation Of Extracellular Matrix Assembly Enzyme-linked Receptor Protein Signaling Pathway Rac Protein Signal Transduction Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Focal Adhesion Assembly Endothelial Cell Differentiation Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Endothelial Cell Proliferation Regulation Of Rac Protein Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Aortic Valve Morphogenesis Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Podosome Regulation Of Protein Targeting To Mitochondrion
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