TIE1 and ANGPT4

Number of citations of the paper that reports this interaction (PMID 10051567)
46

Data Source:
BioGRID (pull down)

		TIE1	ANGPT4
Gene Name		tyrosine kinase with immunoglobulin-like and EGF-like domains 1	angiopoietin 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Tyrosine Kinase Binding
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Signal Transduction Mesoderm Development Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell Migration Response To Retinoic Acid Plasma Membrane Fusion	Angiogenesis Endothelial Cell Proliferation Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Cellular Response To Hypoxia
Pathways			Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ANGPT4 KRT40 MDFI PIK3R1 PSG5 PTPN11 RBPMS TEK	2 interactors: TEK TIE1
Entrez ID		7075	51378
HPRD ID		02572	04747
Ensembl ID		ENSG00000066056	ENSG00000101280
Uniprot IDs		B4DTW8 P35590	B4E3J9 Q9Y264
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Regulation Of Intracellular Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Regulation Of Phosphorylation Regulation Of Protein Transport Leukocyte Migration Regulation Of Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Localization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Import Into Nucleus Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Positive Regulation Of Transport Regulation Of Signaling Positive Regulation Of Intracellular Transport Activation Of Protein Kinase Activity Cell Migration Positive Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Glucose Import Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cell Migration Positive Regulation Of Glucose Transport Positive Regulation Of Cell Motility Positive Regulation Of Protein Transport Positive Regulation Of Cellular Component Movement	Negative Regulation Of Angiogenesis Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Angiogenesis Blood Vessel Morphogenesis Positive Regulation Of Cytokine Secretion Involved In Immune Response Tie Signaling Pathway Blood Vessel Development Vasculature Development Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Actin Cytoskeleton Reorganization Response To Lipid Heart Trabecula Formation Cardiovascular System Development Endothelial Cell Proliferation Plasma Membrane Fusion Peptidyl-amino Acid Modification Definitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Heart Trabecula Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Vascular Permeability Regulation Of Endothelial Cell Apoptotic Process Protein Phosphorylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of NIK/NF-kappaB Signaling Endochondral Ossification Substrate Adhesion-dependent Cell Spreading Regulation Of Focal Adhesion Assembly Positive Regulation Of Cytokine Production Involved In Immune Response Trabecula Morphogenesis Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Migration Regulation Of Lipid Kinase Activity Regulation Of Cell Junction Assembly Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Cytokine Production Involved In Immune Response Organ Regeneration Phosphorylation
Tagcloud ?		algorithm bioinformatics breastmark combines commercially complements datasets dx eliminating epha5 fgfr1 fgfr3 friendly inform integrates mammaprint mirna oncotype pdgfrbeta platforms powerful reductionist robustness superfluous tailor transcriptomic user vegfr1 web
Tagcloud (Difference) ?		algorithm bioinformatics breastmark combines commercially complements datasets dx eliminating epha5 fgfr1 fgfr3 friendly inform integrates mammaprint mirna oncotype pdgfrbeta platforms powerful reductionist robustness superfluous tailor transcriptomic user vegfr1 web
Tagcloud (Intersection) ?