TIE1

Description		tyrosine kinase with immunoglobulin like and EGF like domains 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Mesoderm Development Tissue Development Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Response To Retinoic Acid Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1
Entrez ID		7075
HPRD ID		02572
Ensembl ID		ENSG00000066056
Uniprot IDs		B4DTW8 P35590
PDB IDs		5N06
Enriched GO Terms of Interacting Partners?		Glomerulus Vasculature Development Tie Signaling Pathway Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Glycerolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Endothelial Cell Migration Phosphatidylinositol Metabolic Process Insulin Receptor Binding Regulation Of Intracellular Protein Transport Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Tumor Necrosis Factor Production Cell Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Hemopoiesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-substrate Adhesion Positive Regulation Of D-glucose Import Glycerophospholipid Biosynthetic Process Endothelial Cell Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phospholipid Biosynthetic Process Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Cell Migration Regulation Of Vascular Permeability Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Motility Phosphatidylinositol Phosphate Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Locomotion Vasculature Development Glycerophospholipid Metabolic Process Regulation Of D-glucose Import Regulation Of Endothelial Cell Apoptotic Process Vascular Process In Circulatory System Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade
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