TIE1 and MTMR14

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		TIE1	MTMR14
Description		tyrosine kinase with immunoglobulin like and EGF like domains 1	myotubularin related protein 14
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Ruffle Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Mesoderm Development Tissue Development Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Response To Retinoic Acid Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly	Phosphatidylinositol Biosynthetic Process Macroautophagy
Pathways			Macroautophagy Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Daytime sleep phenotypes ( 27126917)
Interacting Genes		13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1	10 interacting genes: APP CFTR ENO3 EPHA1 EPHA7 EPHB2 LTK TIE1 TP53BP2 UBC
Entrez ID		7075	64419
HPRD ID		02572	08654
Ensembl ID		ENSG00000066056	ENSG00000163719
Uniprot IDs		B4DTW8 P35590	Q8NCE2 Q8WYY9
PDB IDs		5N06
Enriched GO Terms of Interacting Partners?		Glomerulus Vasculature Development Tie Signaling Pathway Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Glycerolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Endothelial Cell Migration Phosphatidylinositol Metabolic Process Insulin Receptor Binding Regulation Of Intracellular Protein Transport Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Tumor Necrosis Factor Production Cell Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Hemopoiesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-substrate Adhesion Positive Regulation Of D-glucose Import Glycerophospholipid Biosynthetic Process Endothelial Cell Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phospholipid Biosynthetic Process Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Cell Migration Regulation Of Vascular Permeability Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Motility Phosphatidylinositol Phosphate Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Locomotion Vasculature Development Glycerophospholipid Metabolic Process Regulation Of D-glucose Import Regulation Of Endothelial Cell Apoptotic Process Vascular Process In Circulatory System Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Ephrin Receptor Activity Receptor Complex Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Kinase Activity Axon Guidance Receptor Activity Neuron Projection Maintenance Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Postsynapse Organization Positive Regulation Of Long-term Synaptic Potentiation ATP Binding Retinal Ganglion Cell Axon Guidance Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Assembly Ephrin Receptor Binding Plasma Membrane Regulation Of Developmental Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Nucleotide Binding Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Hippocampal Mossy Fiber To CA3 Synapse Neuron Recognition Amyloid-beta Complex Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuronal Synaptic Plasticity Regulation Of Cell Junction Assembly Growth Cone Lamellipodium Regulation Of Cell Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Cellular Response To Amyloid-beta Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Axonogenesis Peptidyl-tyrosine Phosphorylation Branching Involved In Lymph Vessel Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Response To Amyloid-beta Regulation Of Synapse Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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