TIE1 and PSG5

Number of citations: 0 (PubMedID 21982860)
Data Source: BioGRID (pull down)

		TIE1	PSG5
Name		tyrosine kinase with immunoglobulin like and EGF like domains 1	pregnancy specific beta-1-glycoprotein 5
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Extracellular Region Cell Surface
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Protein Binding
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Mesoderm Development Tissue Development Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Response To Retinoic Acid Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Female Pregnancy
Pathways		None	Cell surface interactions at the vascular wall
Drugs		Fostamatinib	Alitretinoin
GWAS		Blood protein levels ( 30072576 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Hemoglobin levels ( 32327693 ) Platelet count ( 32888494 ) Red blood cell count ( 32888494 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )	Cerebral microbleeds (lobar) ( 32913026 )
Novel Interactors		None recorded	1 novel interactors: PSMD8
Interacting Genes		13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1	3 interacting genes: NLGN3 PRPF40A TIE1
Entrez ID		7075	5673
HPRD ID		02572	08894
Ensembl ID		ENSG00000066056	ENSG00000204941
Uniprot IDs		B4DTW8 P35590	Q15238
PDB IDs		5N06	Not available
GO Terms Enriched among Interactors		Glomerulus Vasculature Development Tie Signaling Pathway Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Glycerolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Endothelial Cell Migration Phosphatidylinositol Metabolic Process Insulin Receptor Binding Regulation Of Intracellular Protein Transport Sprouting Angiogenesis Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Tumor Necrosis Factor Production Cell Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Hemopoiesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-substrate Adhesion Positive Regulation Of D-glucose Import Glycerophospholipid Biosynthetic Process Endothelial Cell Proliferation Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phospholipid Biosynthetic Process Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Cell Migration Regulation Of Vascular Permeability Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Motility Phosphatidylinositol Phosphate Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Locomotion Vasculature Development Glycerophospholipid Metabolic Process Regulation Of D-glucose Import Regulation Of Endothelial Cell Apoptotic Process Vascular Process In Circulatory System Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade	Proteasome Regulatory Particle, Lid Subcomplex Proteasome Regulatory Particle Branching Involved In Lymph Vessel Morphogenesis Lymphatic Endothelial Cell Differentiation Neurexin Family Protein Binding Asymmetric, Glutamatergic, Excitatory Synapse Regulation Of Respiratory Gaseous Exchange By Nervous System Process Inhibitory Postsynaptic Potential Positive Regulation Of Glutamate Receptor Signaling Pathway Rhythmic Synaptic Transmission Postsynaptic Membrane Assembly Postsynaptic Membrane Organization Presynaptic Membrane Assembly Regulation Of Glutamate Receptor Signaling Pathway Symmetric, GABA-ergic, Inhibitory Synapse Neuron To Neuron Synapse Presynapse Assembly Presynaptic Membrane Organization Proteasome Accessory Complex Regulation Of Respiratory System Process Neuron Cell-cell Adhesion U2-type Prespliceosome MRNA Cis Splicing, Via Spliceosome Presynapse Organization U1 SnRNP Plasma Membrane Fusion Vocalization Behavior Regulation Of Extracellular Matrix Assembly Regulation Of Respiratory Gaseous Exchange