TGM1 and MDK

Number of citations of the paper that reports this interaction (PubMedID 9384573)
52

Data Source:
HPRD (in vitro)

		TGM1	MDK
Description		transglutaminase 1	midkine
Image
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Extracellular Matrix Cell Projection
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Growth Factor Activity Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Binding
	Biological Process	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development	Behavioral Fear Response Leukocyte Chemotaxis Involved In Inflammatory Response T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Nervous System Development Short-term Memory Response To Xenobiotic Stimulus Response To Wounding Response To Hormone Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Hippocampus Development Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Adrenal Gland Development Positive Regulation Of Cell Migration Defecation Regulation Of Chondrocyte Differentiation Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Tissue Regeneration Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Regulation Of Bone Remodeling Oogenesis Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division Positive Regulation Of Cartilage Development Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Inflammatory Response To Wounding Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Neutrophil Extravasation Positive Regulation Of Neuron Migration
Pathways		Formation of the cornified envelope	Signaling by ALK Signaling by ALK NOTCH2 Activation and Transmission of Signal to the Nucleus MDK and PTN in ALK signaling MDK and PTN in ALK signaling
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling miserable ( 29500382) Immunoglobulin A ( 20694011) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	34 interacting genes: ALK AP1M1 CDC42 FBXO7 HCK JAK1 JAK2 JOSD2 LRP1 LRP2 LRP6 LRP8 MAPK6 MIEF2 NCL NFU1 PBX3 PLSCR1 PTPRZ1 RBFA RNF167 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TCEA2 TGM1 TMED8 TSPAN1 UBQLN1 UBQLN2 UBQLN4
Entrez ID		7051	4192
HPRD ID		01824	01200
Ensembl ID		ENSG00000092295	ENSG00000110492
Uniprot IDs		P22735	P21741
PDB IDs		2XZZ	1MKC 1MKN
Enriched GO Terms of Interacting Partners?		Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity	Type II Interferon-mediated Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Cargo Receptor Activity Plasma Membrane Identical Protein Binding Protein Metabolic Process Interferon-mediated Signaling Pathway Caveola Endocytosis Positive Regulation Of Extracellular Exosome Assembly Receptor Complex Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Apoptotic Process Protein Phosphorylation Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Extracellular Exosome Assembly Polyubiquitin Modification-dependent Protein Binding Regulation Of Programmed Cell Death Regulation Of Vesicle-mediated Transport Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Phosphorylation Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Interleukin-7-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Focal Adhesion Growth Hormone Receptor Binding Macromolecule Metabolic Process Import Into Cell Protein Modification Process Regulation Of Lysosomal Protein Catabolic Process Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Insulin Receptor Substrate Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Proteolysis Involved In Protein Catabolic Process Regulation Of Endocytosis Positive Regulation Of Dendrite Development Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Exosomal Secretion Protein Kinase Activity Retinoid Metabolic Process Positive Regulation Of Cell Cycle Interleukin-6-mediated Signaling Pathway Cellular Response To Cholesterol Negative Regulation Of Viral Process Diterpenoid Metabolic Process
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