TGM1 and MDK

Number of citations of the paper that reports this interaction (PMID 9384573)
16

Data Source:
HPRD (in vitro)

		TGM1	MDK
Gene Name		transglutaminase 1	midkine (neurite growth-promoting factor 2)
Image
Gene Ontology Annotations	Cellular Component	Cornified Envelope Cell-cell Adherens Junction Intrinsic Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Cytoplasm Cell Projection
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Metal Ion Binding	Growth Factor Activity Heparin Binding
	Biological Process	Cellular Protein Modification Process Organ Morphogenesis Peptide Cross-linking Keratinocyte Differentiation Keratinization Cell Envelope Organization	Behavioral Fear Response Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Adrenal Gland Development Defecation Response To Drug Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division
Pathways			Signaling by NOTCH2 Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS			Immunoglobulin A ( 20694011)
Protein-Protein Interactions		6 interactors: HSPB1 MDK RARRES3 SEMG1 SEMG2 SNCA	17 interactors: ALK JAK1 JAK2 LRP1 LRP2 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4
Entrez ID		7051	4192
HPRD ID		01824	01200
Ensembl ID		ENSG00000092295	ENSG00000110492
Uniprot IDs		P22735	P21741
PDB IDs		2XZZ	1MKC 1MKN
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Thrombin Receptor Signaling Pathway Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Defecation Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Cellular Respiration Negative Regulation Of Neuron Apoptotic Process Regulation Of Behavior Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Death Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Cell Death Response To Iron(II) Ion Cellular Response To Copper Ion Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Neuron Death Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Oxidative Phosphorylation Positive Regulation Of Inositol Phosphate Biosynthetic Process Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Protein Phosphorylation Dopamine Transport Regulation Of Glutamate Secretion Dopamine Biosynthetic Process Negative Regulation Of Monooxygenase Activity Neurotransmitter Uptake Regulation Of Cellular Respiration Microglial Cell Activation Extracellular Fibril Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Synaptic Transmission, Dopaminergic Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Behavioral Response To Cocaine Short-term Memory Phospholipid Metabolic Process Regulation Of Neurotransmitter Uptake Negative Regulation Of Microtubule Polymerization Positive Regulation Of Neurotransmitter Secretion	Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Extracellular Vesicular Exosome Assembly Response To Light Stimulus Protein Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Response To Radiation System Development Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Stimulus Developmental Process Regulation Of Cytokine-mediated Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Signaling Cell Communication Response To Abiotic Stimulus Multicellular Organismal Development Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transport Response To External Stimulus Growth Hormone Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Cellular Response To Interferon-gamma Cellular Response To Growth Hormone Stimulus Response To Interferon-gamma Glycoprotein Metabolic Process Glycosaminoglycan Metabolic Process Response To Toxic Substance Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Pathogenesis
Tagcloud ?		accelerated b1 block blot cdk4 closely cycle cyclin cytometry displayed explore expressions g0 g1 g2 hacat immortalized immunocytochemistry inmmnohistochemistry interference interfering keratinocytes phases rnai silencing sirna transfecting transglutaminase western	aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic
Tagcloud (Difference) ?		accelerated b1 block blot cdk4 closely cycle cyclin cytometry displayed explore expressions g0 g1 g2 hacat immortalized immunocytochemistry inmmnohistochemistry interference interfering keratinocytes phases rnai silencing sirna transfecting transglutaminase western	aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic
Tagcloud (Intersection) ?