TGM1 and ACADL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGM1	ACADL
Description		transglutaminase 1	acyl-CoA dehydrogenase long chain
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GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding	Acyl-CoA Dehydrogenase Activity Long-chain Fatty Acyl-CoA Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development	Temperature Homeostasis Lipid Metabolic Process Fatty Acid Metabolic Process Lipid Catabolic Process Carnitine Metabolic Process, CoA-linked Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Carnitine Catabolic Process Long-chain Fatty Acid Catabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Fatty Acid Oxidation Regulation Of Cholesterol Metabolic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Formation of the cornified envelope	Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Metabolite levels ( 20037589 23281178) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 23093944) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolites (H-NMR features) ( 24586186)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	1 interacting genes: TGM1
Entrez ID		7051	33
HPRD ID		01824	01939
Ensembl ID		ENSG00000092295	ENSG00000115361
Uniprot IDs		P22735	P28330
PDB IDs		2XZZ	8W0T 8W0U 8W0Z
Enriched GO Terms of Interacting Partners?		Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity	Cell Envelope Organization Protein-glutamine Gamma-glutamyltransferase Activity Peptide Cross-linking Positive Regulation Of Keratinocyte Proliferation Cornified Envelope Keratinization Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Epidermal Cell Differentiation Acyltransferase Activity
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