MDK and SDC3

Number of citations of the paper that reports this interaction (PMID 9089390)
15

Data Source:
HPRD (in vitro)

		MDK	SDC3
Gene Name		midkine (neurite growth-promoting factor 2)	syndecan 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Projection	Golgi Lumen Plasma Membrane Membrane Integral Component Of Membrane Lysosomal Lumen
	Molecular Function	Growth Factor Activity Heparin Binding
	Biological Process	Behavioral Fear Response Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Adrenal Gland Development Defecation Response To Drug Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways		Signaling by NOTCH2 Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)
Protein-Protein Interactions		17 interactors: ALK JAK1 JAK2 LRP1 LRP2 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4	15 interactors: CASK COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN KRTAP10-3 KRTAP5-9 MDK PTN TUBA1A TUBB TUBB2A
Entrez ID		4192	9672
HPRD ID		01200	01719
Ensembl ID		ENSG00000110492
Uniprot IDs		P21741	O75056
PDB IDs		1MKC 1MKN
Enriched GO Terms of Interacting Partners?		Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Extracellular Vesicular Exosome Assembly Response To Light Stimulus Protein Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Response To Radiation System Development Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Detection Of Stimulus Developmental Process Regulation Of Cytokine-mediated Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Signaling Cell Communication Response To Abiotic Stimulus Multicellular Organismal Development Interferon-gamma-mediated Signaling Pathway Anatomical Structure Development Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transport Response To External Stimulus Growth Hormone Receptor Signaling Pathway Positive Regulation Of Organelle Assembly Cellular Response To Interferon-gamma Cellular Response To Growth Hormone Stimulus Response To Interferon-gamma Glycoprotein Metabolic Process Glycosaminoglycan Metabolic Process Response To Toxic Substance Cellular Response To Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Growth Hormone Regulation Of Type I Interferon-mediated Signaling Pathway Pathogenesis	Cell Migration Cell Motility Protein Polymerization Movement Of Cell Or Subcellular Component Nervous System Development Locomotion Anatomical Structure Development Organ Development System Development Developmental Process Response To Wounding Cellular Protein Complex Assembly Multicellular Organismal Development Positive Regulation Of Cell Division Cell Migration Involved In Sprouting Angiogenesis Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Vessel Endothelial Cell Migration Neurogenesis Protein Autophosphorylation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Tissue Development Epithelium Development Neuron Differentiation Wound Healing Chemotaxis Cellular Macromolecular Complex Assembly Neuron Projection Morphogenesis Cell Adhesion Regulation Of Cell Division Learning Or Memory Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Sprouting Angiogenesis 'de Novo' Posttranslational Protein Folding Cognition 'de Novo' Protein Folding Defecation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Integrin Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Defense Response Negative Regulation Of Wound Healing Cellular Response To Peptide T Cell Costimulation Innate Immune Response Neuron Projection Development Endothelial Cell Migration
Tagcloud ?		aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Difference) ?		aacr angiogenic attractive cranialis electrotransfer henceforth heterodimerizing igr intratumor lethal mdkdelta81 midkine mitogenic muscles n91 neovascularization neuroblastoma neurotrophic nude plasmid player portion secretable sh sy5y ther tibialis tractable tumorigenic	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Intersection) ?