MDK and SDC4

Number of citations of the paper that reports this interaction (PubMedID 8621465)
0

Data Source:
HPRD (in vitro)

		MDK	SDC4
Description		midkine	syndecan 4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Cell Projection	Extracellular Region Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Costamere Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Binding	Fibronectin Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Thrombospondin Receptor Activity
	Biological Process	Behavioral Fear Response Leukocyte Chemotaxis Involved In Inflammatory Response T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Nervous System Development Short-term Memory Response To Xenobiotic Stimulus Response To Wounding Response To Hormone Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Hippocampus Development Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Adrenal Gland Development Positive Regulation Of Cell Migration Defecation Regulation Of Chondrocyte Differentiation Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Tissue Regeneration Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Regulation Of Bone Remodeling Oogenesis Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division Positive Regulation Of Cartilage Development Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Inflammatory Response To Wounding Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Neutrophil Extravasation Positive Regulation Of Neuron Migration	Ureteric Bud Development Neural Tube Closure Regulation Of Fibroblast Migration Cell Migration Wound Healing Negative Regulation Of T Cell Proliferation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Inner Ear Receptor Cell Stereocilium Organization Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways		Signaling by ALK Signaling by ALK NOTCH2 Activation and Transmission of Signal to the Nucleus MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling miserable ( 29500382) Immunoglobulin A ( 20694011) Schizophrenia ( 28991256 29483656 30285260)	Malaria ( 31844061) Psoriasis ( 20953189)
Interacting Genes		34 interacting genes: ALK AP1M1 CDC42 FBXO7 HCK JAK1 JAK2 JOSD2 LRP1 LRP2 LRP6 LRP8 MAPK6 MIEF2 NCL NFU1 PBX3 PLSCR1 PTPRZ1 RBFA RNF167 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TCEA2 TGM1 TMED8 TSPAN1 UBQLN1 UBQLN2 UBQLN4	19 interacting genes: CASK CCL5 CXCR4 GIPC1 IL7R MAL MDK PMP22 PRKCA PRKCD PTEN PXN SDCBP SGTA SGTB TANK TGFB1I1 TGFB3 UBC
Entrez ID		4192	6385
HPRD ID		01200	08366
Ensembl ID		ENSG00000110492	ENSG00000124145
Uniprot IDs		P21741	B4E1S6 P31431
PDB IDs		1MKC 1MKN	1EJP 1EJQ 1OBY 1YBO 8BLV
Enriched GO Terms of Interacting Partners?		Type II Interferon-mediated Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Cargo Receptor Activity Plasma Membrane Identical Protein Binding Protein Metabolic Process Interferon-mediated Signaling Pathway Caveola Endocytosis Positive Regulation Of Extracellular Exosome Assembly Receptor Complex Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Apoptotic Process Protein Phosphorylation Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Extracellular Exosome Assembly Polyubiquitin Modification-dependent Protein Binding Regulation Of Programmed Cell Death Regulation Of Vesicle-mediated Transport Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Phosphorylation Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Interleukin-7-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Focal Adhesion Growth Hormone Receptor Binding Macromolecule Metabolic Process Import Into Cell Protein Modification Process Regulation Of Lysosomal Protein Catabolic Process Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Insulin Receptor Substrate Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Proteolysis Involved In Protein Catabolic Process Regulation Of Endocytosis Positive Regulation Of Dendrite Development Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Exosomal Secretion Protein Kinase Activity Retinoid Metabolic Process Positive Regulation Of Cell Cycle Interleukin-6-mediated Signaling Pathway Cellular Response To Cholesterol Negative Regulation Of Viral Process Diterpenoid Metabolic Process	Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition TRC Complex Positive Regulation Of Cell Differentiation Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Population Proliferation Positive Regulation Of Biosynthetic Process Protein Kinase C Signaling Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transport Signal Transduction Regulation Of Smooth Muscle Cell Proliferation Intracellular Signaling Cassette Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Response To Stress Locomotion Cell Migration Regulation Of Response To Wounding Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Programmed Cell Death Cell Death Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Leukocyte Differentiation Regulation Of Cell Activation Positive Regulation Of Developmental Process Schmidt-Lanterman Incisure Regulation Of Proteolysis Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Wound Healing Regulation Of Cell Projection Organization
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