MDK

Name	midkine
Structure
Interactors	34 interactors: ALK AP1M1 CDC42 FBXO7 HCK JAK1 JAK2 JOSD2 LRP1 LRP2 LRP6 LRP8 MAPK6 MIEF2 NCL NFU1 PBX3 PLSCR1 PTPRZ1 RBFA RNF167 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TCEA2 TGM1 TMED8 TSPAN1 UBQLN1 UBQLN2 UBQLN4
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Cell Projection
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Binding
	Biological Process	Behavioral Fear Response Leukocyte Chemotaxis Involved In Inflammatory Response T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Nervous System Development Short-term Memory Response To Xenobiotic Stimulus Response To Wounding Response To Hormone Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Hippocampus Development Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Adrenal Gland Development Positive Regulation Of Cell Migration Defecation Regulation Of Chondrocyte Differentiation Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Tissue Regeneration Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Regulation Of Bone Remodeling Oogenesis Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division Positive Regulation Of Cartilage Development Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Inflammatory Response To Wounding Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Neutrophil Extravasation Positive Regulation Of Neuron Migration
Pathways	Signaling by ALK Signaling by ALK NOTCH2 Activation and Transmission of Signal to the Nucleus MDK and PTN in ALK signaling MDK and PTN in ALK signaling
GWAS	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Feeling miserable ( 29500382 ) Immunoglobulin A ( 20694011 ) Schizophrenia ( 28991256 29483656 30285260 )
Entrez ID	4192
HPRD ID	01200
Ensembl ID	ENSG00000110492
Uniprot IDs	P21741
PDB IDs	1MKC 1MKN
GO Terms Enriched among Interactors ?	Type II Interferon-mediated Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Cargo Receptor Activity Plasma Membrane Identical Protein Binding Protein Metabolic Process Interferon-mediated Signaling Pathway Caveola Endocytosis Positive Regulation Of Extracellular Exosome Assembly Receptor Complex Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Apoptotic Process Protein Phosphorylation Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Extracellular Exosome Assembly Polyubiquitin Modification-dependent Protein Binding Regulation Of Programmed Cell Death Regulation Of Vesicle-mediated Transport Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Phosphorylation Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Interleukin-7-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Focal Adhesion Growth Hormone Receptor Binding Macromolecule Metabolic Process Import Into Cell Protein Modification Process Regulation Of Lysosomal Protein Catabolic Process Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Insulin Receptor Substrate Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Proteolysis Involved In Protein Catabolic Process Regulation Of Endocytosis Positive Regulation Of Dendrite Development Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Exosomal Secretion Protein Kinase Activity Retinoid Metabolic Process Positive Regulation Of Cell Cycle Interleukin-6-mediated Signaling Pathway Cellular Response To Cholesterol Negative Regulation Of Viral Process Diterpenoid Metabolic Process