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TGM1

Description transglutaminase 1
Image
GO Annotations Cellular Component
  • Cornified Envelope
  • Cytosol
  • Plasma Membrane
  • Membrane
  • Extracellular Exosome
Molecular Function
  • Protein-glutamine Gamma-glutamyltransferase Activity
  • Protein Binding
  • Transferase Activity
  • Acyltransferase Activity
  • Identical Protein Binding
  • Metal Ion Binding
Biological Process
  • Positive Regulation Of Keratinocyte Proliferation
  • Peptide Cross-linking
  • Keratinocyte Differentiation
  • Keratinization
  • Protein Modification Process
  • Cell Envelope Organization
  • Positive Regulation Of Cell Cycle
  • Animal Organ Development
Pathways
  • Formation of the cornified envelope
Drugs
Diseases
  • Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS
Interacting Genes 34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4
Entrez ID 7051
HPRD ID 01824
Ensembl ID ENSG00000092295
Uniprot IDs P22735
PDB IDs 2XZZ
Enriched GO Terms of Interacting Partners?
  • Epidermis Development
  • Negative Regulation Of Flagellated Sperm Motility
  • Positive Regulation Of Serine-type Endopeptidase Activity
  • Keratinization
  • Positive Regulation Of Endopeptidase Activity
  • Regulation Of Locomotion
  • Endocytosis
  • Positive Regulation Of Peptidase Activity
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