TGM1 and NUBP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGM1	NUBP2
Description		transglutaminase 1	NUBP iron-sulfur cluster assembly factor 2, cytosolic
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton Cilium Spindle Pole Centrosome Cell Projection
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding Protein Binding ATP Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding ATP-dependent FeS Chaperone Activity
	Biological Process	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development	Iron-sulfur Cluster Assembly Cell Projection Organization
Pathways		Formation of the cornified envelope	Cytosolic iron-sulfur cluster assembly
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Insulin-like growth factors ( 21216879)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	12 interacting genes: CYSRT1 INCA1 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP9-8 MDFI NOTCH2NLA NUBPL PTGER4 TGM1 TNS2
Entrez ID		7051	10101
HPRD ID		01824	14846
Ensembl ID		ENSG00000092295	ENSG00000095906
Uniprot IDs		P22735	B7Z6P0 H3BQR2 Q9Y5Y2
PDB IDs		2XZZ
Enriched GO Terms of Interacting Partners?		Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity	Keratin Filament Intermediate Filament Identical Protein Binding Negative Regulation Of Eosinophil Extravasation Cornified Envelope
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