MDK and JAK1

Number of citations of the paper that reports this interaction (PubMedID 9452495)
0

Data Source:
HPRD (in vitro)

		MDK	JAK1
Description		midkine	Janus kinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Cell Projection	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding CCR5 Chemokine Receptor Binding Metal Ion Binding
	Biological Process	Behavioral Fear Response Leukocyte Chemotaxis Involved In Inflammatory Response T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Nervous System Development Short-term Memory Response To Xenobiotic Stimulus Response To Wounding Response To Hormone Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Cell Migration Dentate Gyrus Development Cerebellar Granular Layer Development Hippocampus Development Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Adrenal Gland Development Positive Regulation Of Cell Migration Defecation Regulation Of Chondrocyte Differentiation Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Tissue Regeneration Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Regulation Of Bone Remodeling Oogenesis Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division Positive Regulation Of Cartilage Development Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Inflammatory Response To Wounding Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Neutrophil Extravasation Positive Regulation Of Neuron Migration	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Response To Antibiotic Regulation Of Multicellular Organismal Process Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Virus Cellular Response To Interleukin-7 Interleukin-10-mediated Signaling Pathway Protein Localization To Cell-cell Junction Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Sprouting Angiogenesis
Pathways		Signaling by ALK Signaling by ALK NOTCH2 Activation and Transmission of Signal to the Nucleus MDK and PTN in ALK signaling MDK and PTN in ALK signaling	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses IFNG signaling activates MAPKs Evasion by RSV of host interferon responses PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs			Myricetin 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Fedratinib Filgotinib Abrocitinib Upadacitinib Pralsetinib Ivarmacitinib
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling miserable ( 29500382) Immunoglobulin A ( 20694011) Schizophrenia ( 28991256 29483656 30285260)	Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Bevacizumab-induced proteinuria ( 34616010) Cognitive function in longevity ( 33607172) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Plasma anti-thyroglobulin levels ( 29678681) Platelet count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		34 interacting genes: ALK AP1M1 CDC42 FBXO7 HCK JAK1 JAK2 JOSD2 LRP1 LRP2 LRP6 LRP8 MAPK6 MIEF2 NCL NFU1 PBX3 PLSCR1 PTPRZ1 RBFA RNF167 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TCEA2 TGM1 TMED8 TSPAN1 UBQLN1 UBQLN2 UBQLN4	77 interacting genes: ABL1 AGTR1 BRCA1 BTK CCR1 CCR5 CISH CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS2 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 STUB1 SYK TEC TNFRSF1A TOP1 TSHR TTC3 TYK2 USP6
Entrez ID		4192	3716
HPRD ID		01200	00992
Ensembl ID		ENSG00000110492	ENSG00000162434
Uniprot IDs		P21741	A0A8V8TPQ9 P23458 Q6P669
PDB IDs		1MKC 1MKN	3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D 6RSB 6RSC 6RSD 6RSE 6RSH 6SM8 6SMB 6TPE 6TPF 6W8L 8EXJ 8S85
Enriched GO Terms of Interacting Partners?		Type II Interferon-mediated Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Cargo Receptor Activity Plasma Membrane Identical Protein Binding Protein Metabolic Process Interferon-mediated Signaling Pathway Caveola Endocytosis Positive Regulation Of Extracellular Exosome Assembly Receptor Complex Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Apoptotic Process Protein Phosphorylation Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Extracellular Exosome Assembly Polyubiquitin Modification-dependent Protein Binding Regulation Of Programmed Cell Death Regulation Of Vesicle-mediated Transport Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Phosphorylation Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Interleukin-7-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Focal Adhesion Growth Hormone Receptor Binding Macromolecule Metabolic Process Import Into Cell Protein Modification Process Regulation Of Lysosomal Protein Catabolic Process Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Insulin Receptor Substrate Binding Cell Surface Receptor Signaling Pathway Via JAK-STAT Proteolysis Involved In Protein Catabolic Process Regulation Of Endocytosis Positive Regulation Of Dendrite Development Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Exosomal Secretion Protein Kinase Activity Retinoid Metabolic Process Positive Regulation Of Cell Cycle Interleukin-6-mediated Signaling Pathway Cellular Response To Cholesterol Negative Regulation Of Viral Process Diterpenoid Metabolic Process	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Cytokine Receptor Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Hemopoiesis Regulation Of Cell Differentiation Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Development Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Immune System Process Cell Activation Receptor Complex Positive Regulation Of Signal Transduction Plasma Membrane Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication External Side Of Plasma Membrane Regulation Of Lymphocyte Differentiation Regulation Of Multicellular Organismal Development Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Phosphorylation Leukocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Protein Phosphorylation Lymphocyte Activation Regulation Of Cell Adhesion
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