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MDK and TSPAN1
Number of citations of the paper that reports this interaction (PubMedID
18851943
)
0
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
MDK
TSPAN1
Description
midkine
tetraspanin 1
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Matrix
Cell Projection
Nucleoplasm
Cytoplasm
Lysosome
Lysosomal Membrane
Plasma Membrane
Membrane
Cell Junction
Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Protein Binding
Growth Factor Activity
Heparin Binding
Chondroitin Sulfate Binding
Heparan Sulfate Binding
Protein Binding
Biological Process
Behavioral Fear Response
Leukocyte Chemotaxis Involved In Inflammatory Response
T Cell Activation Involved In Immune Response
Positive Regulation Of Leukocyte Chemotaxis
Cytoskeleton Organization
Negative Regulation Of Cell Adhesion
Signal Transduction
Nervous System Development
Short-term Memory
Response To Xenobiotic Stimulus
Response To Wounding
Response To Hormone
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Keratinocyte Proliferation
Positive Regulation Of Neuron Projection Development
Response To Auditory Stimulus
Cell Migration
Dentate Gyrus Development
Cerebellar Granular Layer Development
Hippocampus Development
Cerebral Cortex Development
Cell Differentiation
Negative Regulation Of Ossification
Adrenal Gland Development
Positive Regulation Of Cell Migration
Defecation
Regulation Of Chondrocyte Differentiation
Positive Regulation Of Interleukin-12 Production
Intracellular Signal Transduction
Tissue Regeneration
Negative Regulation Of Neuron Apoptotic Process
Estrous Cycle
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Cell Adhesion
Positive Regulation Of DNA-templated Transcription
Regulation Of Bone Remodeling
Oogenesis
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Regulation Of Behavior
Response To Glucocorticoid
Positive Regulation Of Cell Division
Positive Regulation Of Cartilage Development
Positive Regulation Of Smooth Muscle Cell Chemotaxis
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Inflammatory Response To Wounding
Glial Cell Projection Elongation
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Artery Morphogenesis
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Hepatocyte Proliferation
Positive Regulation Of Neutrophil Extravasation
Positive Regulation Of Neuron Migration
Protein Stabilization
Pathways
Signaling by ALK
Signaling by ALK
NOTCH2 Activation and Transmission of Signal to the Nucleus
MDK and PTN in ALK signaling
MDK and PTN in ALK signaling
Drugs
Diseases
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Feeling miserable (
29500382
)
Immunoglobulin A (
20694011
)
Schizophrenia (
28991256
29483656
30285260
)
Body mass index (
26426971
)
Interacting Genes
34 interacting genes:
ALK
AP1M1
CDC42
FBXO7
HCK
JAK1
JAK2
JOSD2
LRP1
LRP2
LRP6
LRP8
MAPK6
MIEF2
NCL
NFU1
PBX3
PLSCR1
PTPRZ1
RBFA
RNF167
RPL18A
SDC1
SDC3
SDC4
SRPK2
STAT1
TCEA2
TGM1
TMED8
TSPAN1
UBQLN1
UBQLN2
UBQLN4
4 interacting genes:
MDK
NFKBIB
TFAM
TMEM80
Entrez ID
4192
10103
HPRD ID
01200
18232
Ensembl ID
ENSG00000110492
ENSG00000117472
Uniprot IDs
P21741
O60635
PDB IDs
1MKC
1MKN
Enriched GO Terms of Interacting Partners
?
Type II Interferon-mediated Signaling Pathway
Low-density Lipoprotein Particle Receptor Activity
Cargo Receptor Activity
Plasma Membrane
Identical Protein Binding
Protein Metabolic Process
Interferon-mediated Signaling Pathway
Caveola
Endocytosis
Positive Regulation Of Extracellular Exosome Assembly
Receptor Complex
Positive Regulation Of Lysosomal Protein Catabolic Process
Regulation Of Apoptotic Process
Protein Phosphorylation
Regulation Of Oligodendrocyte Progenitor Proliferation
Regulation Of Extracellular Exosome Assembly
Polyubiquitin Modification-dependent Protein Binding
Regulation Of Programmed Cell Death
Regulation Of Vesicle-mediated Transport
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of Protein Catabolic Process In The Vacuole
Phosphorylation
Interleukin-9-mediated Signaling Pathway
CCR5 Chemokine Receptor Binding
Interleukin-7-mediated Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Tyrosine Kinase Activity
Peptidyl-tyrosine Phosphorylation
Focal Adhesion
Growth Hormone Receptor Binding
Macromolecule Metabolic Process
Import Into Cell
Protein Modification Process
Regulation Of Lysosomal Protein Catabolic Process
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Insulin Receptor Substrate Binding
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Proteolysis Involved In Protein Catabolic Process
Regulation Of Endocytosis
Positive Regulation Of Dendrite Development
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Exosomal Secretion
Protein Kinase Activity
Retinoid Metabolic Process
Positive Regulation Of Cell Cycle
Interleukin-6-mediated Signaling Pathway
Cellular Response To Cholesterol
Negative Regulation Of Viral Process
Diterpenoid Metabolic Process
Regulation Of Neutrophil Extravasation
Chondroitin Sulfate Binding
Positive Regulation Of Artery Morphogenesis
Glial Cell Projection Elongation
Defecation
Positive Regulation Of Neutrophil Extravasation
Cerebellar Granular Layer Development
Leukocyte Chemotaxis Involved In Inflammatory Response
Regulation Of Artery Morphogenesis
Positive Regulation Of Smooth Muscle Cell Chemotaxis
Positive Regulation Of Blood Vessel Branching
Negative Regulation Of Regulatory T Cell Differentiation
Regulation Of Blood Vessel Branching
Negative Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Inflammatory Response To Wounding
Heparan Sulfate Binding
Positive Regulation Of Hepatocyte Proliferation
Mitochondrial Transcription
Mitochondrial Promoter Sequence-specific DNA Binding
Mitochondrial Transcription Factor Activity
Transcription Initiation At Mitochondrial Promoter
Histone H3K36me2/H3K36me3 Demethylase Activity
Histone H3K9 Demethylase Activity
Histone H4K20me2 Reader Activity
Histone H3K36 Demethylase Activity
Histone H3K9me2/H3K9me3 Demethylase Activity
Estrous Cycle
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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