TGM1 and TRAPPC14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGM1	TRAPPC14
Description		transglutaminase 1	trafficking protein particle complex subunit 14
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome	Cytoplasm Spindle Cytoskeleton Plasma Membrane Midbody Vesicle Centriolar Satellite Mitotic Spindle TRAPPII Protein Complex
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Alpha-tubulin Binding
	Biological Process	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development	Cell Projection Organization Regulation Of Cell Population Proliferation Cilium Assembly
Pathways		Formation of the cornified envelope
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	8 interacting genes: AGXT CYSRT1 KRTAP6-1 NBPF19 NOTCH2NLA TGM1 TMEM50A VWC2
Entrez ID		7051	55262
HPRD ID		01824	07716
Ensembl ID		ENSG00000092295	ENSG00000146826
Uniprot IDs		P22735	B3KNS5 Q8WVR3
PDB IDs		2XZZ
Enriched GO Terms of Interacting Partners?		Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity	Glycine Biosynthetic Process, By Transamination Of Glyoxylate L-serine-pyruvate Transaminase Activity Oxalic Acid Secretion Cornified Envelope Positive Regulation Of Cell Cycle Keratinization Cell Envelope Organization Set3 Complex Positive Regulation Of Cell Cycle G1/S Phase Transition Rpd3L-Expanded Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle RNA 5'-gamma-phosphate Methyltransferase Activity Glycine Biosynthetic Process Notch Signaling Pathway Glyoxylate Catabolic Process L-alanine Catabolic Process Alanine-glyoxylate Transaminase Activity L-alanine Metabolic Process L-cysteine Catabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP SnRNA Modification Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle O-methyltransferase Activity Interstitial Matrix Oxalate Transport Glyoxylate Metabolic Process Extrinsic Component Of Postsynaptic Membrane Regulation Of Cell Cycle G1/S Phase Transition 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body Sulfur Amino Acid Catabolic Process Cysteine Metabolic Process Serine Family Amino Acid Catabolic Process SnRNA Binding
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