TGM1 and CRCT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGM1	CRCT1
Description		transglutaminase 1	cysteine rich C-terminal 1
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development
Pathways		Formation of the cornified envelope
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 21804549 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Obesity-related traits ( 23251661) Plantar warts ( 28928442)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	62 interacting genes: AGTRAP ALPP APLP1 CEP126 CHD3 CYP21A2 CYSRT1 EEF1A1 GRN IGSF21 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE3A LCE4A LRIF1 MACO1 MEOX2 NOTCH2NLA NUP62 OIT3 PLSCR4 PTN RGS17 RGS20 SDCBP2 SLC39A7 TGM1 TLE1 TRIM55 TRIM63 VIM VWC2L
Entrez ID		7051	54544
HPRD ID		01824	16635
Ensembl ID		ENSG00000092295	ENSG00000169509
Uniprot IDs		P22735	Q9UGL9
PDB IDs		2XZZ
Enriched GO Terms of Interacting Partners?		Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Tissue Development Identical Protein Binding Protein Binding Positive Regulation Of Axon Regeneration
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