TGFB1I1 and SVIL

Number of citations: 41 (PubMedID 11792840)
Data Source: HPRD (in vivo)

		TGFB1I1	SVIL
Name		transforming growth factor beta 1 induced transcript 1	supervillin
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Nuclear Matrix Extracellular Matrix Anchoring Junction	Podosome Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Midbody Cleavage Furrow Microtubule Minus-end Cell Projection Costamere Anchoring Junction
	Molecular Function	Transcription Coactivator Activity Protein Binding Metal Ion Binding Roundabout Binding Nuclear Androgen Receptor Binding I-SMAD Binding	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Epithelial Cell Differentiation Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Cytoskeleton Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping Muscle Structure Development
GWAS		Metabolite levels ( 23823483 )	Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Bone fracture in osteoporosis ( 28580392 ) Dilated cardiomyopathy ( 33495596 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Estimated glomerular filtration rate ( 31152163 ) Lung function (FEV1/FVC) ( 28166213 ) Metabolite levels ( 23823483 ) Neurofibrillary tangles ( 25188341 ) Normalized brain volume ( 19010793 ) Platelet thrombus formation ( 22550155 ) Plateletcrit ( 32888494 )
Novel Interactors		2 novel interactors: DOC2A ST3GAL3	1 novel interactors: SLAMF7
Interacting Genes		33 interacting genes: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HOXA1 HSPB1 ITCH ITGA4 MAPK15 NEDD4 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL YAP1	36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TMEM132D TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		7041	6840
HPRD ID		03831	04992
Ensembl ID		ENSG00000140682	ENSG00000197321
Uniprot IDs		O43294	A0A6I8PIX7 O95425 Q569J5
PDB IDs		Not available	2K6M 2K6N
GO Terms Enriched among Interactors		Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Developmental Process Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Adhesion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Anchoring Junction Regulation Of Multicellular Organismal Process Response To Growth Factor Negative Regulation Of Signal Transduction Cell Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Tolerance Induction Type I Transforming Growth Factor Beta Receptor Binding Cellular Response To Growth Factor Stimulus Leukocyte Activation Positive Regulation Of Tolerance Induction Regulation Of Cell Population Proliferation Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of T Cell Tolerance Induction Anatomical Structure Morphogenesis Transferase Activity Costamere Negative Regulation Of Cell-cell Adhesion Regulation Of Protein Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Cell Adhesion Plasma Membrane Proline-rich Region Binding Cytosol Regulation Of Immune System Process Regulation Of Tolerance Induction Negative Regulation Of T Cell Activation Developmental Growth Protein Modification Process Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of T Cell Activation Positive Regulation Of Catabolic Process Regulation Of Apoptotic Process Tissue Morphogenesis	Organelle Organization Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Cytoskeleton Identical Protein Binding Nucleus Regulation Of Organelle Organization Nuclear Receptor Activity Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Cytoplasm Regulation Of Apoptotic Process Steroid Binding Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Pore Localization Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Cytosol Cell Death Programmed Cell Death Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process Spindle Regulation Of Gene Expression Regulation Of Chromosome Organization Nuclear Matrix Cytoskeleton Organization Prostate Gland Growth Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Intracellular Protein Localization Chromosome Segregation Microtubule Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule-based Process Microtubule Motor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Response To Estrogen Chromatin Organization Nuclear Lamina Microtubule Cytoskeleton Organization Negative Regulation Of Apoptotic Process