TGFB1I1 and PLA2G3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		TGFB1I1	PLA2G3
Description		transforming growth factor beta 1 induced transcript 1	phospholipase A2 group III
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Nuclear Matrix Extracellular Matrix Anchoring Junction	Extracellular Region Extracellular Space Cytoplasm Endosome Centriole Cytoskeleton Plasma Membrane Membrane Recycling Endosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Metal Ion Binding Roundabout Binding Nuclear Androgen Receptor Binding I-SMAD Binding	Phospholipase Activity Phospholipase A2 Activity Hydrolase Activity Metal Ion Binding Calcium-dependent Phospholipase A2 Activity
	Biological Process	Cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Epithelial Cell Differentiation Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Acrosome Assembly Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylserine Metabolic Process Sperm Axoneme Assembly Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Neuron Projection Development Lipoxygenase Pathway Cell Projection Organization Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Macrophage Activation Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Phosphatidylinositol Metabolic Process Cell Development Cell Maturation Arachidonate Secretion Cilium Assembly Positive Regulation Of Mast Cell Differentiation Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Endocytic Recycling
Pathways			Acyl chain remodelling of PC Acyl chain remodelling of PE Acyl chain remodelling of PG
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Appendicular lean mass ( 33097823) Fish- and plant-related diet ( 32066663) Gut microbiota (beta diversity) ( 27723756) Oily fish consumption ( 32066663) Paclitaxel-induced neuropathy ( 23776197) Pork consumption ( 32066663)
Interacting Genes		33 interacting genes: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HOXA1 HSPB1 ITCH ITGA4 MAPK15 NEDD4 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL YAP1	3 interacting genes: BTG3 PVR TGFB1I1
Entrez ID		7041	50487
HPRD ID		03831	07144
Ensembl ID		ENSG00000140682	ENSG00000100078
Uniprot IDs		O43294	Q9NZ20
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Developmental Process Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Adhesion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Anchoring Junction Regulation Of Multicellular Organismal Process Response To Growth Factor Negative Regulation Of Signal Transduction Cell Activation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell-cell Adhesion Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Tolerance Induction Type I Transforming Growth Factor Beta Receptor Binding Cellular Response To Growth Factor Stimulus Leukocyte Activation Positive Regulation Of Tolerance Induction Regulation Of Cell Population Proliferation Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of T Cell Tolerance Induction Anatomical Structure Morphogenesis Transferase Activity Costamere Negative Regulation Of Cell-cell Adhesion Regulation Of Protein Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Regulation Of Alpha-beta T Cell Activation Positive Regulation Of Cell Adhesion Plasma Membrane Proline-rich Region Binding Cytosol Regulation Of Immune System Process Regulation Of Tolerance Induction Negative Regulation Of T Cell Activation Developmental Growth Protein Modification Process Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Regulation Of T Cell Activation Positive Regulation Of Catabolic Process Regulation Of Apoptotic Process Tissue Morphogenesis	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Susceptibility To T Cell Mediated Cytotoxicity Susceptibility To Natural Killer Cell Mediated Cytotoxicity Roundabout Binding Focal Adhesion Cell Adhesion Mediator Activity Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Immune Response To Tumor Cell Negative Regulation Of Cell Population Proliferation Nuclear Androgen Receptor Binding I-SMAD Binding Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Morphogenesis Of Embryonic Epithelium
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