TGFB1I1 and SLC6A3

Number of citations of the paper that reports this interaction (PMID 12177201)
25

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TGFB1I1	SLC6A3
Gene Name		transforming growth factor beta 1 induced transcript 1	solute carrier family 6 (neurotransmitter transporter), member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Cytoskeleton Focal Adhesion Nuclear Matrix Extracellular Matrix	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Axon Neuronal Cell Body
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Roundabout Binding Androgen Receptor Binding I-SMAD Binding	Protease Binding Receptor Binding Dopamine Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Protein Binding Drug Binding Monoamine Transmembrane Transporter Activity Protein Complex Binding Dopamine Binding Protein N-terminus Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Cell Adhesion Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Epithelial Cell Differentiation Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated	Neurotransmitter Transport Synaptic Transmission Aging Lactation Sensory Perception Of Smell Locomotory Behavior Response To Iron Ion Monoamine Transport Dopamine Transport Adenohypophysis Development Response To Nicotine Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Neurotransmitter Biosynthetic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Drug Response To Ethanol Response To CAMP Transmembrane Transport Prepulse Inhibition Ammonium Transmembrane Transport Cation Transmembrane Transport
Pathways			Na+/Cl- dependent neurotransmitter transporters Dopamine clearance from the synaptic cleft Neurotransmitter Clearance In The Synaptic Cleft Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds SLC-mediated transmembrane transport Transmission across Chemical Synapses
Drugs			Amphetamine Phentermine Benzatropine Venlafaxine Methylphenidate Duloxetine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Lisdexamfetamine Ephedra MMDA 3,4-Methylenedioxymethamphetamine Fencamfamine 4-Methoxyamphetamine Dextroamphetamine Methamphetamine Nomifensine Dexmethylphenidate
Diseases
GWAS
Protein-Protein Interactions		29 interactors: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HSPB1 ITGA4 MAPK15 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL	8 interactors: DRD2 GNB2L1 NEDD4 PICK1 SNCA SNTA1 STX1A TGFB1I1
Entrez ID		7041	6531
HPRD ID		03831	00543
Ensembl ID		ENSG00000140682	ENSG00000142319
Uniprot IDs		O43294	Q01959
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Cell Activation Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Signal Transduction Response To Stimulus Regulation Of Catalytic Activity Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Organ Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Cell Surface Receptor Signaling Pathway System Development Response To Transforming Growth Factor Beta Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Anatomical Structure Development Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Negative Regulation Of Signaling Cellular Response To Stimulus Multicellular Organismal Development Regulation Of Cellular Process Positive Regulation Of Protein Kinase Activity Developmental Process Positive Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation	Regulation Of Vesicle-mediated Transport Synapse Organization Regulation Of Cellular Component Organization Regulation Of Endocytosis Receptor Internalization Negative Regulation Of Signaling Negative Regulation Of Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Synaptic Transmission Receptor Metabolic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Ion Transport Positive Regulation Of Endocytosis Regulation Of Signaling Negative Regulation Of Transport Positive Regulation Of Synaptic Transmission Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Cellular Localization Regulation Of Neurotransmitter Uptake Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Positive Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Receptor Internalization Regulation Of Dopamine Secretion Regulation Of Ion Homeostasis Regulation Of Synaptic Plasticity Synaptic Transmission Regulation Of Ion Transport Monoamine Transport Dopamine Metabolic Process Regulation Of Response To Reactive Oxygen Species Vesicle-mediated Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Receptor Internalization Response To Iron Ion Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Transporter Activity Regulation Of Synaptic Vesicle Transport Catecholamine Metabolic Process Regulation Of Cellular Response To Oxidative Stress Response To Cocaine Cell-cell Signaling Positive Regulation Of Secretion Neuromuscular Junction Development
Tagcloud ?		aii aiii aiiis aiis astrocytoma astrocytomas beta1 bioinformatics biomarker contributing emt focused grade grades idh1 integration malignant microarrays multistep nbt progress progression qpcr shrna tp53 transcript transition validated	adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic trajectories variations
Tagcloud (Difference) ?		aii aiii aiiis aiis astrocytoma astrocytomas beta1 bioinformatics biomarker contributing emt focused grade grades idh1 integration malignant microarrays multistep nbt progress progression qpcr shrna tp53 transcript transition validated	adra1d aminobutyric attentional caregivers catecholaminergic classes covariates departments descriptive encode ergic gaba gabaergic genotypic htr2a latent membership multivariable neurotransmission oncology rs2296972 rs2697138 rs37022 rs4815675 rs9534496 serotonergic trajectories variations
Tagcloud (Intersection) ?