TGFB1 and KRTAP1-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGFB1	KRTAP1-3
Description		transforming growth factor beta 1	keratin associated protein 1-3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Secretory Granule Axon Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body Blood Microparticle	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Deubiquitinase Activator Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Ureteric Bud Development Response To Hypoxia Morphogenesis Of A Branching Structure Cell Activation Epithelial To Mesenchymal Transition Neural Tube Closure Regulation Of Sodium Ion Transport Sprouting Angiogenesis Chondrocyte Differentiation Columnar/cuboidal Epithelial Cell Maturation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tolerance Induction To Self Antigen Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Heart Valve Morphogenesis Aortic Valve Morphogenesis Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis Apoptotic Process Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Negative Regulation Of Neuroblast Proliferation Salivary Gland Morphogenesis Endoderm Development Heart Development Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Germ Cell Migration Response To Xenobiotic Stimulus Response To Wounding Response To Glucose Gene Expression Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Negative Regulation Of Macrophage Cytokine Production Oligodendrocyte Development Positive Regulation Of Microglia Differentiation Regulation Of Striated Muscle Tissue Development Neural Tube Development Hyaluronan Catabolic Process T Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Osteoclast Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Mammary Gland Development Animal Organ Regeneration Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Exit From Mitosis Response To Estradiol Response To Progesterone Regulation Of Interleukin-23 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Mononuclear Cell Proliferation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Response To Vitamin D Response To Laminar Fluid Shear Stress Response To Immobilization Stress Myofibroblast Differentiation T Cell Proliferation T Cell Activation Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Myelination T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulatory T Cell Differentiation Cell-cell Junction Organization Response To Ethanol Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Digestive Tract Development Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Inner Ear Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Fungus Negative Regulation Of T Cell Activation Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Component Organization Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Regulation Of Cell Cycle Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ventricular Cardiac Muscle Tissue Morphogenesis Phospholipid Homeostasis Canonical Wnt Signaling Pathway Regulation Of Blood Vessel Remodeling Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Bronchiole Development Mammary Gland Branching Involved In Thelarche Branch Elongation Involved In Mammary Gland Duct Branching Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Connective Tissue Development Langerhans Cell Differentiation Negative Regulation Of Biomineral Tissue Development Regulation Of Enamel Mineralization Lens Fiber Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mononuclear Cell Migration Odontoblast Differentiation Stem Cell Proliferation Extracellular Matrix Assembly Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Liver Regeneration Cellular Response To Virus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Extracellular Matrix Assembly Response To Salt Positive Regulation Of Mesenchymal Stem Cell Proliferation Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vasculature Development Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cellular Response To Acetaldehyde Cellular Response To Insulin-like Growth Factor Stimulus Embryonic Liver Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Primary MiRNA Processing Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions ECM proteoglycans SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Transcriptional regulation of white adipocyte differentiation UCH proteinases Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF TGFBR3 regulates TGF-beta signaling	Keratinization
Drugs		Hyaluronidase (ovine) Terazosin Hyaluronidase (human recombinant) Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Hyaluronidase
Diseases		Graft-versus-host disease Allograft rejection Camurati-Engelmann disease; Progressive diaphyseal dysplasia
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Colorectal cancer ( 24836286 27145994) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 28714974 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Platelet count ( 32888494) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30578418) Type 2 diabetes ( 31049640)
Interacting Genes		99 interacting genes: ACVRL1 ADAMTSL4 AGR3 ANGPTL4 APC APP AURKA AXIN2 BCAS3 BCL10 BGN BLID BMP2 BMP3 BMPR1A BUB1 CATSPER1 CCDC33 CCL3 CCL5 CCN2 CDKN2A CFTR COL2A1 CST6 CYSRT1 DAXX DCN DIRAS3 DLC1 DPT EGFR EIF3I ENG ERBB2 FBXW7 FCHO1 FCN1 FKBP1A FMOD FNTA GREB1 HOXA1 HOXC6 ITGAV ITGB6 ITGB8 KLK5 KLK7 KLK9 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP4-11 LAMTOR5 LCE1A LCE1C LCE1D LCE1F LCE2B LCE2C LCE3A LCE3B LCE3D LCE5A LPXN LTBP1 LTBP3 LTBP4 MCC MEOX2 MLH3 MMP2 MTA3 NSD3 P4HB PDGFRL PDLIM2 POU4F2 PRSS50 PSMC3IP PZP RAPGEF3 SCGB3A1 SDC2 SNAI1 SPARC ST14 TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 THRSP TLR2 UBC VASN VTN YWHAE	183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837
Entrez ID		7040	81850
HPRD ID		01821	12305
Ensembl ID		ENSG00000105329	ENSG00000221880
Uniprot IDs		A0A499FJK2 P01137	Q8IUG1
PDB IDs		1KLA 1KLC 1KLD 3KFD 4KV5 5FFO 5VQP 6OM2 6P7J 7Y1R 7Y1T 8UDZ 8VSC 8VSD 9FDY 9FKP
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Binding Tissue Development Epidermis Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Developmental Process Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Extracellular Matrix Cell Surface Receptor Signaling Pathway Keratinization Endocardial Cushion Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Positive Regulation Of SMAD Protein Signal Transduction Extracellular Space Regulation Of Cell Migration Cardiac Epithelial To Mesenchymal Transition Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Extracellular Matrix Organization Extracellular Structure Organization Activin Binding Positive Regulation Of Cell Migration Glycosaminoglycan Binding Regulation Of Multicellular Organismal Process Regulation Of Epithelial Cell Proliferation Response To Growth Factor Cell Surface Positive Regulation Of Cell Motility Regulation Of SMAD Protein Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Locomotion Extracellular Region Regulation Of Programmed Cell Death Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Roof Of Mouth Development Extracellular Matrix Binding Regulation Of Apoptotic Process Regulation Of Signal Transduction Epithelial To Mesenchymal Transition Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis	Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding
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