TGFB1 and ITGAV

Number of citations of the paper that reports this interaction (PMID 11970960)
154

Data Source:
HPRD (in vivo)

		TGFB1	ITGAV
Gene Name		transforming growth factor, beta 1	integrin, alpha V
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Axon Platelet Alpha Granule Lumen Neuronal Cell Body Blood Microparticle	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta8 Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding Antigen Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein N-terminus Binding	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Voltage-gated Calcium Channel Activity Protein Binding Insulin-like Growth Factor I Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Ureteric Bud Development Response To Hypoxia Epithelial To Mesenchymal Transition Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Sodium Ion Transport Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tolerance Induction To Self Antigen Platelet Degranulation Protein Phosphorylation Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Cellular Calcium Ion Homeostasis Inflammatory Response Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Neuroblast Proliferation Salivary Gland Morphogenesis Endoderm Development Female Pregnancy Aging Blood Coagulation Negative Regulation Of DNA Replication Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Germ Cell Migration Response To Radiation Response To Wounding Response To Glucose Defense Response To Fungus, Incompatible Interaction Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Cell Growth Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Modulation By Virus Of Host Morphology Or Physiology Evasion Or Tolerance Of Host Defenses By Virus Viral Life Cycle Negative Regulation Of Cell-cell Adhesion Platelet Activation Extracellular Matrix Organization Hyaluronan Catabolic Process Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Organ Regeneration Positive Regulation Of Protein Complex Assembly Positive Regulation Of Exit From Mitosis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Response To Progesterone Positive Regulation Of Interleukin-17 Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Mononuclear Cell Proliferation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin D Response To Laminar Fluid Shear Stress Positive Regulation Of Histone Acetylation Positive Regulation Of Protein Dephosphorylation Negative Regulation Of T Cell Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Odontogenesis Response To Drug Myelination Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Ossification Involved In Bone Remodeling Regulatory T Cell Differentiation Cell-cell Junction Organization Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Active Induction Of Host Immune Response By Virus Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Digestive Tract Development Negative Regulation Of Skeletal Muscle Tissue Development Inner Ear Development Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Phagocytosis Positive Regulation Of Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Binding Regulation Of DNA Binding Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Blood Vessel Remodeling Face Morphogenesis Frontal Suture Morphogenesis Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Mammary Gland Branching Involved In Thelarche Branch Elongation Involved In Mammary Gland Duct Branching Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cartilage Development Lens Fiber Cell Differentiation Response To Cholesterol Positive Regulation Of Cell Cycle Arrest Cellular Response To Organic Cyclic Compound Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Extracellular Matrix Assembly Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Regulatory Region DNA Binding	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Cell Growth Cell Migration Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Apoptotic Cell Clearance Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Cell Adhesion Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Leukocyte Migration Negative Chemotaxis Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Apoptotic Cell Clearance Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Elastic fibre formation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation TGF-beta receptor signaling activates SMADs Host Interactions with Influenza Factors TGFBR1 LBD Mutants in Cancer Influenza Virus Induced Apoptosis Molecules associated with elastic fibres ECM proteoglycans Response to elevated platelet cytosolic Ca2+ Transcriptional regulation of white adipocyte differentiation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Non-integrin membrane-ECM interactions Influenza Infection Loss of Function of TGFBR1 in Cancer Syndecan interactions Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer	Signal transduction by L1 Axon guidance Elastic fibre formation L1CAM interactions Non-integrin membrane-ECM interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Laminin interactions Signaling by VEGF ECM proteoglycans Integrin cell surface interactions Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs		Hyaluronidase
Diseases
GWAS
Protein-Protein Interactions		39 interactors: ACVRL1 APP BGN BMP2 BMP3 CCDC33 CCL3 COL2A1 CTGF DAXX DCN DPT EIF3I ENG FCN1 FKBP1A FMOD FNTA ITGAV ITGB6 ITGB8 LAMB1 LTBP1 LTBP3 LTBP4 MEOX2 MMP2 MMP9 PZP SDC2 SPARC TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 VASN VTN YWHAE	28 interactors: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CD47 CYR61 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM MMP14 MMP2 NID1 NOV P2RY2 PAK4 PDGFRA PLP1 PTK2 SPP1 TGFB1 THY1
Entrez ID		7040	3685
HPRD ID		01821	01903
Ensembl ID			ENSG00000138448
Uniprot IDs		P01137	B7ZLX0 P06756
PDB IDs		1KLA 1KLC 1KLD 3KFD	1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cell Surface Receptor Signaling Pathway Skeletal System Development Cardiovascular System Development Tissue Development Regulation Of Locomotion Multicellular Organismal Development Regulation Of Cellular Component Movement Anatomical Structure Formation Involved In Morphogenesis Locomotion Regulation Of Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Cellular Response To Organic Substance Regulation Of Cell Motility Regulation Of Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Response To Growth Factor Stimulus Blood Vessel Development Response To Organic Substance Vasculature Development Response To Stimulus Response To Abiotic Stimulus Organ Development Developmental Process System Development Cellular Response To Stimulus Angiogenesis Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Metabolic Process Signal Transduction Positive Regulation Of Locomotion Organ Morphogenesis Anatomical Structure Development Movement Of Cell Or Subcellular Component Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding	Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Cell-matrix Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Locomotion Regulation Of Cell-substrate Adhesion Cardiovascular System Development Blood Vessel Development Response To External Stimulus Vasculature Development Single Organismal Cell-cell Adhesion Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Developmental Process Blood Vessel Morphogenesis Cell Migration Tissue Development Cell Motility Angiogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Development Signaling Cell Communication Response To Stimulus Positive Regulation Of Cell Proliferation Signal Transduction Chemotaxis Wound Healing Organ Development Blood Coagulation Hemostasis System Development Cell-cell Adhesion Mediated By Integrin Single Organism Reproductive Process Response To Wounding Positive Regulation Of Kinase Activity Anatomical Structure Morphogenesis
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25	bcl colorectal corresponding crc dissemination event extracellular ihc immunohistochemistry invasion ki matrix metastasis neoplastic overexpression perineural polymerase progression quantitative real regard resection sparc spread thbs1 underwent validation vcam vegf
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