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TGFB1 and BMP3
Number of citations of the paper that reports this interaction (PubMedID
9434787
)
0
Data Source:
HPRD
(in vivo)
TGFB1
BMP3
Description
transforming growth factor beta 1
bone morphogenetic protein 3
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Plasma Membrane
Microvillus
Cell Surface
Secretory Granule
Axon
Extracellular Matrix
Platelet Alpha Granule Lumen
Neuronal Cell Body
Blood Microparticle
Extracellular Region
Extracellular Space
Extracellular Exosome
Molecular Function
Type II Transforming Growth Factor Beta Receptor Binding
Cytokine Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Growth Factor Activity
Enzyme Binding
Type I Transforming Growth Factor Beta Receptor Binding
Type III Transforming Growth Factor Beta Receptor Binding
Deubiquitinase Activator Activity
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Protein-containing Complex Binding
Signaling Receptor Binding
Cytokine Activity
Growth Factor Activity
BMP Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Vasculogenesis
Ureteric Bud Development
Response To Hypoxia
Morphogenesis Of A Branching Structure
Cell Activation
Epithelial To Mesenchymal Transition
Neural Tube Closure
Regulation Of Sodium Ion Transport
Sprouting Angiogenesis
Chondrocyte Differentiation
Columnar/cuboidal Epithelial Cell Maturation
Hematopoietic Progenitor Cell Differentiation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Tolerance Induction To Self Antigen
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Heart Valve Morphogenesis
Aortic Valve Morphogenesis
Protein Export From Nucleus
ATP Biosynthetic Process
Phosphate-containing Compound Metabolic Process
Intracellular Calcium Ion Homeostasis
Apoptotic Process
Inflammatory Response
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Negative Regulation Of Neuroblast Proliferation
Salivary Gland Morphogenesis
Endoderm Development
Heart Development
Female Pregnancy
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Germ Cell Migration
Response To Xenobiotic Stimulus
Response To Wounding
Response To Glucose
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Epithelial To Mesenchymal Transition
Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Fibroblast Migration
Negative Regulation Of Macrophage Cytokine Production
Oligodendrocyte Development
Positive Regulation Of Microglia Differentiation
Regulation Of Striated Muscle Tissue Development
Neural Tube Development
Hyaluronan Catabolic Process
T Cell Differentiation
Negative Regulation Of Ossification
Negative Regulation Of Cell Growth
Osteoclast Differentiation
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Mammary Gland Development
Animal Organ Regeneration
Membrane Protein Intracellular Domain Proteolysis
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Exit From Mitosis
Response To Estradiol
Response To Progesterone
Regulation Of Interleukin-23 Production
Negative Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Receptor Catabolic Process
Positive Regulation Of Superoxide Anion Generation
Mononuclear Cell Proliferation
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Response To Vitamin D
Response To Laminar Fluid Shear Stress
Response To Immobilization Stress
Myofibroblast Differentiation
T Cell Proliferation
T Cell Activation
Regulation Of Cell Population Proliferation
Negative Regulation Of T Cell Proliferation
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Protein Import Into Nucleus
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of Odontogenesis
Myelination
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of Vascular Permeability
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Surfactant Homeostasis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulatory T Cell Differentiation
Cell-cell Junction Organization
Response To Ethanol
Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Regulatory T Cell Differentiation
Negative Regulation Of Cell Differentiation
Positive Regulation Of Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Muscle Cell Cellular Homeostasis
Positive Regulation Of Fibroblast Proliferation
Lung Alveolus Development
Positive Regulation Of Isotype Switching To IgA Isotypes
Lymph Node Development
Digestive Tract Development
Negative Regulation Of Skeletal Muscle Tissue Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Inner Ear Development
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Inflammatory Response
Negative Regulation Of Phagocytosis
Defense Response To Fungus
Negative Regulation Of T Cell Activation
Positive Regulation Of Chemotaxis
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Regulation Of Cell Cycle
Positive Regulation Of Cell Division
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Ventricular Cardiac Muscle Tissue Morphogenesis
Phospholipid Homeostasis
Canonical Wnt Signaling Pathway
Regulation Of Blood Vessel Remodeling
Face Morphogenesis
Frontal Suture Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Bronchiole Development
Mammary Gland Branching Involved In Thelarche
Branch Elongation Involved In Mammary Gland Duct Branching
Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
Regulation Of Cartilage Development
Retina Vasculature Development In Camera-type Eye
Connective Tissue Development
Langerhans Cell Differentiation
Negative Regulation Of Biomineral Tissue Development
Regulation Of Enamel Mineralization
Lens Fiber Cell Differentiation
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Cholesterol
Cellular Response To Mechanical Stimulus
Cellular Response To Glucose Stimulus
Cellular Response To Growth Factor Stimulus
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Hypoxia
Cellular Response To Ionizing Radiation
Cellular Response To Dexamethasone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Mononuclear Cell Migration
Odontoblast Differentiation
Stem Cell Proliferation
Extracellular Matrix Assembly
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Liver Regeneration
Cellular Response To Virus
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Negative Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Extracellular Matrix Assembly
Response To Salt
Positive Regulation Of Mesenchymal Stem Cell Proliferation
Regulation Of MiRNA Transcription
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Vasculature Development
Positive Regulation Of Receptor Signaling Pathway Via STAT
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cellular Response To Acetaldehyde
Cellular Response To Insulin-like Growth Factor Stimulus
Embryonic Liver Development
Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Primary MiRNA Processing
Positive Regulation Of Stem Cell Proliferation
Positive Regulation Of Cardiac Muscle Cell Differentiation
Skeletal System Development
Ossification
Osteoblast Differentiation
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell-cell Signaling
Cell Differentiation
Negative Regulation Of Ossification
Positive Regulation Of Transcription By RNA Polymerase II
Cartilage Development
Pathways
Platelet degranulation
Influenza Virus Induced Apoptosis
Cell surface interactions at the vascular wall
Molecules associated with elastic fibres
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Syndecan interactions
ECM proteoglycans
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Transcriptional regulation of white adipocyte differentiation
UCH proteinases
Interleukin-4 and Interleukin-13 signaling
RUNX3 regulates CDKN1A transcription
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
TGFBR3 regulates TGF-beta signaling
Drugs
Hyaluronidase (ovine)
Terazosin
Hyaluronidase (human recombinant)
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Hyaluronidase
Diseases
Graft-versus-host disease
Allograft rejection
Camurati-Engelmann disease; Progressive diaphyseal dysplasia
GWAS
Alanine aminotransferase levels (
34315874
)
Aspartate aminotransferase levels (
34315874
)
Colorectal cancer (
24836286
27145994
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
28714974
29212778
33020668
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Hematuria (
30476138
)
Hematuria (mild) (
30476138
)
Hematuria (moderate to severe) (
30476138
)
Platelet count (
32888494
)
Preterm birth (maternal effect) (
28877031
)
Pulse pressure (
30578418
)
Type 2 diabetes (
31049640
)
Cataracts (
34127677
)
Corneal astigmatism (
30306274
)
Height (
18391951
)
Low myopia vs hyperopia (
33830181
)
Myopia (
27182965
)
Optic disc size (
31809533
)
Pubertal anthropometrics (
23449627
)
Refractive astigmatism (
30306274
)
Refractive error (
23396134
32231278
)
Retinal detachment or retinal break (
31816047
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Interacting Genes
99 interacting genes:
ACVRL1
ADAMTSL4
AGR3
ANGPTL4
APC
APP
AURKA
AXIN2
BCAS3
BCL10
BGN
BLID
BMP2
BMP3
BMPR1A
BUB1
CATSPER1
CCDC33
CCL3
CCL5
CCN2
CDKN2A
CFTR
COL2A1
CST6
CYSRT1
DAXX
DCN
DIRAS3
DLC1
DPT
EGFR
EIF3I
ENG
ERBB2
FBXW7
FCHO1
FCN1
FKBP1A
FMOD
FNTA
GREB1
HOXA1
HOXC6
ITGAV
ITGB6
ITGB8
KLK5
KLK7
KLK9
KRTAP1-1
KRTAP1-3
KRTAP10-8
KRTAP4-11
LAMTOR5
LCE1A
LCE1C
LCE1D
LCE1F
LCE2B
LCE2C
LCE3A
LCE3B
LCE3D
LCE5A
LPXN
LTBP1
LTBP3
LTBP4
MCC
MEOX2
MLH3
MMP2
MTA3
NSD3
P4HB
PDGFRL
PDLIM2
POU4F2
PRSS50
PSMC3IP
PZP
RAPGEF3
SCGB3A1
SDC2
SNAI1
SPARC
ST14
TGFB2
TGFBR1
TGFBR2
TGFBR3
THBS1
THRSP
TLR2
UBC
VASN
VTN
YWHAE
5 interacting genes:
COL4A1
COL4A2
KDM1A
PRMT6
TGFB1
Entrez ID
7040
651
HPRD ID
01821
00208
Ensembl ID
ENSG00000105329
ENSG00000152785
Uniprot IDs
A0A499FJK2
P01137
P12645
PDB IDs
1KLA
1KLC
1KLD
3KFD
4KV5
5FFO
5VQP
6OM2
6P7J
7Y1R
7Y1T
8UDZ
8VSC
8VSD
9FDY
9FKP
2QCQ
Enriched GO Terms of Interacting Partners
?
Transforming Growth Factor Beta Binding
Tissue Development
Epidermis Development
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Formation Involved In Morphogenesis
Developmental Process
Transforming Growth Factor Beta Receptor Activity
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Extracellular Matrix
Cell Surface Receptor Signaling Pathway
Keratinization
Endocardial Cushion Morphogenesis
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Locomotion
Regulation Of Cell Motility
Positive Regulation Of SMAD Protein Signal Transduction
Extracellular Space
Regulation Of Cell Migration
Cardiac Epithelial To Mesenchymal Transition
Anatomical Structure Morphogenesis
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Extracellular Matrix Organization
Extracellular Structure Organization
Activin Binding
Positive Regulation Of Cell Migration
Glycosaminoglycan Binding
Regulation Of Multicellular Organismal Process
Regulation Of Epithelial Cell Proliferation
Response To Growth Factor
Cell Surface
Positive Regulation Of Cell Motility
Regulation Of SMAD Protein Signal Transduction
Animal Organ Morphogenesis
Positive Regulation Of Locomotion
Extracellular Region
Regulation Of Programmed Cell Death
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Roof Of Mouth Development
Extracellular Matrix Binding
Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Epithelial To Mesenchymal Transition
Heart Morphogenesis
Cardiac Muscle Tissue Morphogenesis
Collagen Type IV Trimer
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Collagen-activated Signaling Pathway
Extracellular Structure Organization
Extracellular Matrix Organization
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Angiogenesis
Regulation Of Neuroblast Proliferation
Positive Regulation Of Stem Cell Proliferation
Extracellular Matrix
Collagen Trimer
Response To Transforming Growth Factor Beta
Cellular Response To Transforming Growth Factor Beta Stimulus
Branch Elongation Involved In Mammary Gland Duct Branching
Positive Regulation Of Microglia Differentiation
Cellular Response To Ionizing Radiation
Epithelial To Mesenchymal Transition
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Stem Cell Proliferation
Cellular Response To Acetaldehyde
Histone H2AR3 Methyltransferase Activity
Basement Membrane
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Neural Precursor Cell Proliferation
Extracellular Matrix Structural Constituent
Regulation Of Multicellular Organismal Development
Positive Regulation Of Primary MiRNA Processing
Negative Regulation Of RNA Metabolic Process
Embryonic Liver Development
Regulation Of Epithelial To Mesenchymal Transition
Mesenchymal Cell Differentiation
Telomeric Repeat-containing RNA Binding
FAD-dependent H3K4me/H3K4me3 Demethylase Activity
Histone H3R2 Methyltransferase Activity
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Multicellular Organismal Process
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Frontal Suture Morphogenesis
Response To Ionizing Radiation
Regulation Of DNA Recombination
Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
Histone Arginine N-methyltransferase Activity
Regulation Of Cold-induced Thermogenesis
Morphogenesis Of A Branching Epithelium
Cell Maturation
Morphogenesis Of A Branching Structure
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