KRTAP1-3 and WNT11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP1-3	WNT11
Description		keratin associated protein 1-3	Wnt family member 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Extracellular Region Extracellular Space Cytoplasm Extracellular Matrix
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Kinase Activator Activity
	Biological Process		Osteoblast Differentiation Kidney Development Epithelial To Mesenchymal Transition Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Ventricular Septum Development Atrial Septum Development Apoptotic Process Signal Transduction Wnt Signaling Pathway, Calcium Modulating Pathway Mesenchymal Cell Proliferation Wnt Signaling Pathway Cell Differentiation Neuron Differentiation Bone Mineralization Adrenal Gland Development Response To Nutrient Levels Positive Regulation Of Transforming Growth Factor Beta2 Production Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Cell Fate Commitment Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of DNA-templated Transcription Paraxial Mesoderm Formation Notochord Morphogenesis Embryonic Skeletal System Development Artery Morphogenesis Roof Of Mouth Development Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cloacal Septation Ventricular Septum Morphogenesis Lung-associated Mesenchyme Development Ureteric Bud Morphogenesis Negative Regulation Of Cartilage Development Somite Development Neuroendocrine Cell Differentiation Secondary Palate Development Bicellular Tight Junction Assembly Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Stem Cell Proliferation Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Production Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Stem Cell Proliferation
Pathways		Keratinization	WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Formation of the ureteric bud
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Platelet count ( 32888494) Plateletcrit ( 32888494) PR interval ( 20062060 30046033 32439900) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Thumb osteoarthritis severity (hand Klsum) ( 33055079)
Interacting Genes		183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837	17 interacting genes: CCNDBP1 CYSRT1 FUCA2 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP9-3 MDFI RASSF10
Entrez ID		81850	7481
HPRD ID		12305	04741
Ensembl ID		ENSG00000221880	ENSG00000085741
Uniprot IDs		Q8IUG1	M4IS22 O96014
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding	Intermediate Filament Keratin Filament Cytosol Identical Protein Binding Structural Constituent Of Skin Epidermis Alpha-L-fucosidase Activity
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