KRTAP1-3 and ALDH3B1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP1-3	ALDH3B1
Description		keratin associated protein 1-3	aldehyde dehydrogenase 3 family member B1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Cytoplasm Cytosol Plasma Membrane Membrane Secretory Granule Membrane Vesicle Specific Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase (NADP+) Activity Benzaldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase (NADP+) Activity Long-chain Fatty Aldehyde Dehydrogenase (NAD+) Activity Medium-chain Fatty Aldehyde Dehydrogenase (NAD+) Activity
	Biological Process		Alcohol Metabolic Process Ethanol Catabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Response To Oxidative Stress Sphingolipid Catabolic Process Cellular Response To Oxidative Stress Aldehyde Catabolic Process
Pathways		Keratinization	Neutrophil degranulation Sphingolipid catabolism
Drugs			NADH
Diseases
GWAS			Serum uric acid levels ( 32514006)
Interacting Genes		183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837	18 interacting genes: CYSRT1 HSD17B10 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP3-3 KRTAP4-2 KRTAP5-9 MID2 NOTCH2NLA
Entrez ID		81850	221
HPRD ID		12305	02716
Ensembl ID		ENSG00000221880	ENSG00000006534
Uniprot IDs		Q8IUG1	A0A087X2D4 P43353
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Epidermis Development Structural Molecule Activity Cytosol Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Mitochondrial RNA 5'-end Processing
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