TGFB1 and CCDC33

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		TGFB1	CCDC33
Gene Name		transforming growth factor, beta 1	coiled-coil domain containing 33
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Axon Platelet Alpha Granule Lumen Neuronal Cell Body Blood Microparticle
	Molecular Function	Glycoprotein Binding Antigen Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein N-terminus Binding	Protein Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Ureteric Bud Development Response To Hypoxia Epithelial To Mesenchymal Transition Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Sodium Ion Transport Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tolerance Induction To Self Antigen Platelet Degranulation Protein Phosphorylation Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Cellular Calcium Ion Homeostasis Inflammatory Response Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Neuroblast Proliferation Salivary Gland Morphogenesis Endoderm Development Female Pregnancy Aging Blood Coagulation Negative Regulation Of DNA Replication Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Germ Cell Migration Response To Radiation Response To Wounding Response To Glucose Defense Response To Fungus, Incompatible Interaction Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Cell Growth Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Modulation By Virus Of Host Morphology Or Physiology Evasion Or Tolerance Of Host Defenses By Virus Viral Life Cycle Negative Regulation Of Cell-cell Adhesion Platelet Activation Extracellular Matrix Organization Hyaluronan Catabolic Process Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Organ Regeneration Positive Regulation Of Protein Complex Assembly Positive Regulation Of Exit From Mitosis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Response To Progesterone Positive Regulation Of Interleukin-17 Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Mononuclear Cell Proliferation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin D Response To Laminar Fluid Shear Stress Positive Regulation Of Histone Acetylation Positive Regulation Of Protein Dephosphorylation Negative Regulation Of T Cell Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Odontogenesis Response To Drug Myelination Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Ossification Involved In Bone Remodeling Regulatory T Cell Differentiation Cell-cell Junction Organization Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Active Induction Of Host Immune Response By Virus Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Digestive Tract Development Negative Regulation Of Skeletal Muscle Tissue Development Inner Ear Development Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Phagocytosis Positive Regulation Of Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Binding Regulation Of DNA Binding Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Blood Vessel Remodeling Face Morphogenesis Frontal Suture Morphogenesis Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Mammary Gland Branching Involved In Thelarche Branch Elongation Involved In Mammary Gland Duct Branching Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cartilage Development Lens Fiber Cell Differentiation Response To Cholesterol Positive Regulation Of Cell Cycle Arrest Cellular Response To Organic Cyclic Compound Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Extracellular Matrix Assembly Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Loss of Function of TGFBR2 in Cancer Elastic fibre formation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation TGF-beta receptor signaling activates SMADs Host Interactions with Influenza Factors TGFBR1 LBD Mutants in Cancer Influenza Virus Induced Apoptosis Molecules associated with elastic fibres ECM proteoglycans Response to elevated platelet cytosolic Ca2+ Transcriptional regulation of white adipocyte differentiation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Non-integrin membrane-ECM interactions Influenza Infection Loss of Function of TGFBR1 in Cancer Syndecan interactions Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer
Drugs		Hyaluronidase
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		39 interactors: ACVRL1 APP BGN BMP2 BMP3 CCDC33 CCL3 COL2A1 CTGF DAXX DCN DPT EIF3I ENG FCN1 FKBP1A FMOD FNTA ITGAV ITGB6 ITGB8 LAMB1 LTBP1 LTBP3 LTBP4 MEOX2 MMP2 MMP9 PZP SDC2 SPARC TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 VASN VTN YWHAE	91 interactors: ABCF3 ABLIM3 APP ARIH2 ARMC7 ARNT2 BCCIP BLK BLZF1 BYSL CALCOCO2 CCDC102B CCDC85B CCNH CDCA7L CDKN2B CENPP CHCHD3 DGCR6 DIP2A DVL2 EFEMP2 EHMT2 EMC2 EMD FAM124A FAM161A FXR2 GPATCH2L GRN HGS HNRNPF HNRNPK HOOK2 HOXA1 ING5 KANK2 KCTD19 KCTD9 KHDRBS3 KIFC3 KXD1 LDOC1 LMO2 LMO3 MAGED1 MAPK9 MDFI MIPOL1 MOS NAB2 NCK2 NDOR1 NECAB2 NINL OSGIN1 PID1 PIN1 PLSCR1 PNMA1 PNMA2 POLR1C PPP2R3C PRKAB2 PTGER3 PTK6 RAD54B RBMX RHOXF2 SCNM1 SMAD3 SPAG5 SPG21 SSSCA1 STK16 STX11 TGFB1 TMCC2 TRAF2 TRIM37 TRIM42 TSC22D4 TSGA10 TTC19 TUFT1 UBQLN4 USHBP1 VPS52 ZBTB8A ZGPAT ZNF572
Entrez ID		7040	80125
HPRD ID		01821	09959
Ensembl ID			ENSG00000140481
Uniprot IDs		P01137	Q8N5R6
PDB IDs		1KLA 1KLC 1KLD 3KFD
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cell Surface Receptor Signaling Pathway Skeletal System Development Cardiovascular System Development Tissue Development Regulation Of Locomotion Multicellular Organismal Development Regulation Of Cellular Component Movement Anatomical Structure Formation Involved In Morphogenesis Locomotion Regulation Of Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Cellular Response To Organic Substance Regulation Of Cell Motility Regulation Of Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Response To Growth Factor Stimulus Blood Vessel Development Response To Organic Substance Vasculature Development Response To Stimulus Response To Abiotic Stimulus Organ Development Developmental Process System Development Cellular Response To Stimulus Angiogenesis Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Metabolic Process Signal Transduction Positive Regulation Of Locomotion Organ Morphogenesis Anatomical Structure Development Movement Of Cell Or Subcellular Component Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding	Regulation Of Gene Expression Regulation Of Protein Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Phosphorylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Protein Kinase Activity Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Phosphorus Metabolic Process RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Proliferation Negative Regulation Of Phosphorylation Cellular Nitrogen Compound Metabolic Process Immune System Process Transcription From RNA Polymerase II Promoter Cell Cycle Process Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Cellular Process Regulation Of Cell Cycle Response To Organic Substance Organelle Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of MAP Kinase Activity Nitrogen Compound Metabolic Process Negative Regulation Of Protein Phosphorylation
Tagcloud ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
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