KRTAP1-3 and INS

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KRTAP1-3	INS
Name		keratin associated protein 1-3	insulin
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Transport Vesicle Endosome Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Secretory Granule Lumen
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	Protease Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Hormone Activity Protein Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	None	Positive Regulation Of Cytokine Production Negative Regulation Of Acute Inflammatory Response Glucose Metabolic Process Regulation Of DNA-templated Transcription Acute-phase Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Protein Localization Nitric Oxide-cGMP-mediated Signaling TORC1 Signaling Wound Healing Negative Regulation Of Protein Catabolic Process Vasodilation Glucose Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Translation Negative Regulation Of Glycogen Catabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Alpha-beta T Cell Activation Positive Regulation Of Lipid Biosynthetic Process Regulation Of Synaptic Plasticity Regulation Of Protein Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Protein Secretion Cognition Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fatty Acid Homeostasis Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Respiratory Burst Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Long-term Synaptic Potentiation Cellular Response To Oxygen-containing Compound Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dendritic Spine Maintenance Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Feeding Behavior
Pathways		Keratinization	Regulation of gene expression in beta cells Insulin processing Insulin processing Synthesis, secretion, and deacylation of Ghrelin Regulation of insulin secretion COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NPAS4 regulates expression of target genes Amyloid fiber formation
Drugs		None	Glisoxepide Zinc M-Cresol Myristic acid Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		None	Permanent neonatal diabetes mellitus (PNDM) Type I diabetes mellitus Maturity onset diabetes of the young (MODY)
GWAS		No GWAS studies recorded	Birth weight ( 27680694 ) Celiac disease ( 23936387 ) Fasting glucose ( 34059833 ) Glycated hemoglobin levels ( 34059833 ) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083 ) Pediatric autoimmune diseases ( 26301688 ) Prostate cancer ( 19767753 ) Prostate cancer (SNP x SNP interaction) ( 22219177 ) Severe autoimmune type 2 diabetes ( 34737425 ) Type 1 diabetes ( 25751624 21829393 30659077 31152121 32005708 33830302 19430480 17632545 17554260 ) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926 ) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926 ) Type 2 diabetes ( 30297969 30718926 31049640 31324766 32499647 )
Novel Interactors		None recorded	1 novel interactors: HRAS
Interacting Genes		183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837	32 interacting genes: ADAMTSL4 APP CCN3 CPE CRYAB CTSB CTSD CTSE CYSRT1 GCK HLA-DQA2 HLA-DQB1 HSPA1A HSPB1 IDE IGF1R IGFBP7 INSR KMT2A KRTAP1-1 KRTAP1-3 KRTAP10-8 LRP2 MAPK6 NBPF19 NOTCH2NLA PTEN RB1 RGS20 SYTL4 TCF4 TXNDC17
Entrez ID		81850	3630
HPRD ID		12305	01455
Ensembl ID		ENSG00000221880	ENSG00000254647
Uniprot IDs		Q8IUG1	I3WAC9 P01308
PDB IDs		Not available	1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1JK8 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1SJU 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2G54 2G56 2H67 2HH4 2HHO 2HIU 2JMN 2JUM 2JUU 2JUV 2JV1 2JZQ 2K91 2K9R 2KJJ 2KJU 2KQP 2KQQ 2KXK 2L1Y 2L1Z 2LGB 2LWZ 2M1D 2M1E 2M2M 2M2N 2M2O 2M2P 2MLI 2MPG 2MPI 2MVC 2MVD 2N2V 2N2W 2N2X 2OLY 2OLZ 2OM0 2OM1 2OMG 2OMH 2OMI 2OMQ 2QIU 2R34 2R35 2R36 2RN5 2VJZ 2VK0 2W44 2WBY 2WC0 2WRU 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 3BXQ 3E7Y 3E7Z 3EXX 3FQ9 3HYD 3I3Z 3I40 3ILG 3INC 3IR0 3JSD 3KQ6 3P2X 3P33 3Q6E 3ROV 3TT8 3U4N 3UTQ 3UTS 3UTT 3V19 3V1G 3W11 3W12 3W13 3W7Y 3W7Z 3W80 3ZI3 3ZQR 3ZS2 3ZU1 4AIY 4AJX 4AJZ 4AK0 4AKJ 4CXL 4CXN 4CY7 4EFX 4EWW 4EWX 4EWZ 4EX0 4EX1 4EXX 4EY1 4EY9 4EYD 4EYN 4EYP 4F0N 4F0O 4F1A 4F1B 4F1C 4F1D 4F1F 4F1G 4F4T 4F4V 4F51 4F8F 4FG3 4FKA 4GBC 4GBI 4GBK 4GBL 4GBN 4IUZ 4IYD 4IYF 4NIB 4OGA 4P65 4RXW 4UNE 4UNG 4UNH 4WDI 4XC4 4Y19 4Y1A 4Z76 4Z77 4Z78 5AIY 5BOQ 5BPO 5BQQ 5BTS 5C0D 5CJO 5CNY 5CO2 5CO6 5CO9 5E7W 5EMS 5EN9 5ENA 5HPR 5HPU 5HQI 5HRQ 5HYJ 5MAM 5MHD 5MT3 5MT9 5MWQ 5T7R 5UDP 5UOZ 5UQA 5URT 5URU 5USP 5USS 5USV 5UU2 5UU3 5UU4 5VIZ 5WBT 5WDM 5WOB 6B3Q 6B70 6BFC 6CE7 6CE9 6CEB 6CK2 6GNQ 6GV0 6H3M 6HN5 6JK8 6JR3 6K59 6NWV 6O17 6P4Z 6S34 6S4I 6S4J 6SOF 6TC2 6TYH 6U46 6VEP 6VER 6VES 6VET 6X4X 6Z7W 6Z7Y 7BW7 7BW8 7BWA 7JP3 7KD6 7MD4 7MD5 7MQO 7MQR 7MQS 7NHU 7NMG 7PG0 7PG2 7PG3 7PG4 7QAC 7QGF 7QID 7RKD 7RZE 7RZF 7RZI 7S4Y 7SL1 7SL2 7SL3 7SL4 7SL6 7SL7 7STH 7STI 7STJ 7STK 7U6E 7V3P 7YQ3 7YQ4 7YQ5 7Z5L 7Z5Q 8EYX 8EYY 8EZ0 8GSG 8GUY 8HGZ 8HSF 8HSK 8IPZ 8OKY 8ONI 8ONK 8ONP 8ONR 8PI4 8PI5 8PI6 8PJH 8RRP 8RVT 8SBD 8VCX 8VDD 8WU0 8Z4B 9LVC 9LVD 9LVE 9LVX 9LVY 9M4X 9M4Y 9M4Z 9M50 9M51
GO Terms Enriched among Interactors		Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding	Insulin Binding Antigen Processing And Presentation Of Peptide Antigen Amyloid-beta Clearance Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Neuron Projection Organization Antigen Processing And Presentation Identical Protein Binding Insulin-like Growth Factor I Binding Antigen Processing And Presentation Of Exogenous Antigen Lysosome Transport Vesicle Membrane Insulin Metabolic Process PTB Domain Binding Endosome Lumen Insulin Receptor Activity Regulation Of Growth Insulin Receptor Signaling Pathway Protein Refolding Insulin Catabolic Process Insulin Receptor Complex Dendritic Spine Organization Cellular Response To Hormone Stimulus Regulation Of Apoptotic Process Negative Regulation Of Cell Population Proliferation Extracellular Exosome Regulation Of Programmed Cell Death Negative Regulation Of Growth Signal Transduction Symbiont Entry Into Host Cell Postsynapse Organization Regulation Of Generation Of Precursor Metabolites And Energy MHC Class II Receptor Activity Regulation Of Glycolytic Process Response To Hormone Intracellular Signaling Cassette Regulation Of Cell Population Proliferation Regulation Of Neuronal Synaptic Plasticity Cellular Response To Growth Factor Stimulus Insulin-like Growth Factor Binding Dendritic Spine Maintenance Regulation Of Cell Communication Regulation Of Signaling Biological Process Involved In Interaction With Host Regulation Of Carbohydrate Catabolic Process Neuron Projection Maintenance Neurexin Family Protein Binding Contractile Muscle Fiber