KRTAP1-3 and DAGLB

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		KRTAP1-3	DAGLB
Description		keratin associated protein 1-3	diacylglycerol lipase beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Nucleoplasm Lysosomal Membrane Plasma Membrane Membrane
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	Triacylglycerol Lipase Activity Protein Binding Lipase Activity Hydrolase Activity Metal Ion Binding Monoacylglycerol Lipase Activity
	Biological Process		Prostaglandin Biosynthetic Process Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Icosanoid Metabolic Process Neuroblast Proliferation Positive Regulation Of Triglyceride Catabolic Process Lipid Catabolic Process Arachidonate Metabolic Process Neurogenesis Diacylglycerol Catabolic Process Regulation Of Inflammatory Response Cannabinoid Biosynthetic Process
Pathways		Keratinization	Arachidonate production from DAG
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Body mass index ( 26426971) Coronary artery disease ( 29212778) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 27863252) Red cell distribution width ( 32888494) Ulcerative colitis ( 28067908) Waist-hip ratio and HDL-C (pairwise) ( 33619380) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		183 interacting genes: ADAM12 AGA ALDH3B1 ALPP ATG9A BCAM BHLHE40 BMP7 BTC C19orf25 C2orf68 CATSPER1 CELF5 CHIC2 CHRD CHRNG CLDN2 CMTM8 CNNM3 COA5 COL8A1 CRCT1 CREB5 CRH CRY2 CTNNBIP1 CXCL16 CYP21A2 CYSRT1 DAGLB DHRS1 DLGAP3 DMRT3 DOCK2 ECE1 EMC7 FBXW5 FZD10 GLP1R GLRX3 GLYAT GNE GRAP2 GSTP1 HCK HHEX HHIPL1 HOXA1 HOXB9 HOXC8 HPCAL1 HSD3B7 IGSF8 IL10 IL16 INPP5D INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KPRP KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LONRF1 LRFN4 MAPKBP1 MOS MTNR1A MXD3 MXI1 MYPOP NAXD NECTIN2 NECTIN3 NID2 NMU NPBWR2 NPDC1 NR1D2 NUFIP2 OLFM2 OTX1 P3H3 PDE9A PDIA5 PHETA1 PHLDA1 PIGS PLEKHN1 PRF1 PRKAA2 PRKAB2 PRPF31 PSMA1 PTK7 PTPMT1 PVR R3HDM2 RAMAC RANBP3 RASD1 RPN1 RPS19BP1 SAPCD2 SDC3 SDCBP SELENOM SHFL SLC13A5 SLC22A23 SLC23A1 SLC39A7 SLC43A2 SLC5A5 SLC7A11 SMCP SPINT1 SPRY1 STK16 SUSD6 TACSTD2 TCAF1 TFAP2D TGFB1 THAP7 TNS2 UNC119 UTP23 UXT VASN VSTM4 WNT11 XCL2 YIPF3 YY1 ZDHHC1 ZFTRAF1 ZNF330 ZNF414 ZNF417 ZNF440 ZNF446 ZNF497 ZNF587 ZNF696 ZNF764 ZNF786 ZNF837	5 interacting genes: CLP1 KRTAP1-3 NBPF19 NOTCH2NLA PISD
Entrez ID		81850	221955
HPRD ID		12305	17324
Ensembl ID		ENSG00000221880	ENSG00000164535
Uniprot IDs		Q8IUG1	Q8NCG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Epidermis Development Keratinization Protein Binding Intermediate Filament Keratin Filament Tissue Development Hair Cycle Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Animal Organ Morphogenesis Negative Regulation Of Defense Response Identical Protein Binding	ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity Phosphatidylserine Decarboxylase Activity TRNA-intron Endonuclease Complex Global Gene Silencing By MRNA Cleavage ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity MRNA Cleavage Factor Complex Cerebellar Cortex Development RISC Complex Assembly Phosphatidylethanolamine Biosynthetic Process Mitochondrial Protein Catabolic Process TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Lipid Droplet Formation Protein Autoprocessing Carboxy-lyase Activity Notch Binding
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