TGFB1 and YWHAE

Number of citations of the paper that reports this interaction (PubMedID 11172812)
0

Data Source:
HPRD (in vivo)

		TGFB1	YWHAE
Description		transforming growth factor beta 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Secretory Granule Axon Extracellular Matrix Platelet Alpha Granule Lumen Neuronal Cell Body Blood Microparticle	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Membrane Mitochondrial Membrane Melanosome Extracellular Exosome
	Molecular Function	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Deubiquitinase Activator Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding	RNA Binding Protein Phosphatase Inhibitor Activity Calcium Channel Regulator Activity Protein Binding Potassium Channel Regulator Activity Calcium Channel Inhibitor Activity Enzyme Binding Protein Phosphatase Binding Protein Domain Specific Binding MHC Class II Protein Complex Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Histone Deacetylase Binding Transmembrane Transporter Binding Cadherin Binding Protein Heterodimerization Activity Phosphoserine Residue Binding Phosphoprotein Binding Scaffold Protein Binding Protein Sequestering Activity Molecular Function Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Vasculogenesis Ureteric Bud Development Response To Hypoxia Morphogenesis Of A Branching Structure Cell Activation Epithelial To Mesenchymal Transition Neural Tube Closure Regulation Of Sodium Ion Transport Sprouting Angiogenesis Chondrocyte Differentiation Columnar/cuboidal Epithelial Cell Maturation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tolerance Induction To Self Antigen Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Heart Valve Morphogenesis Aortic Valve Morphogenesis Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis Apoptotic Process Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Negative Regulation Of Neuroblast Proliferation Salivary Gland Morphogenesis Endoderm Development Heart Development Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Germ Cell Migration Response To Xenobiotic Stimulus Response To Wounding Response To Glucose Gene Expression Regulation Of Gene Expression Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Negative Regulation Of Macrophage Cytokine Production Oligodendrocyte Development Positive Regulation Of Microglia Differentiation Regulation Of Striated Muscle Tissue Development Neural Tube Development Hyaluronan Catabolic Process T Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Growth Osteoclast Differentiation Regulation Of Cell Migration Positive Regulation Of Cell Migration Mammary Gland Development Animal Organ Regeneration Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Exit From Mitosis Response To Estradiol Response To Progesterone Regulation Of Interleukin-23 Production Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Mononuclear Cell Proliferation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Response To Vitamin D Response To Laminar Fluid Shear Stress Response To Immobilization Stress Myofibroblast Differentiation T Cell Proliferation T Cell Activation Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Odontogenesis Myelination T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of Canonical NF-kappaB Signal Transduction Surfactant Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulatory T Cell Differentiation Cell-cell Junction Organization Response To Ethanol Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Digestive Tract Development Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Smooth Muscle Cell Proliferation Inner Ear Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Defense Response To Fungus Negative Regulation Of T Cell Activation Positive Regulation Of Chemotaxis Positive Regulation Of Cellular Component Organization Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Regulation Of Cell Cycle Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Ventricular Cardiac Muscle Tissue Morphogenesis Phospholipid Homeostasis Canonical Wnt Signaling Pathway Regulation Of Blood Vessel Remodeling Face Morphogenesis Frontal Suture Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Bronchiole Development Mammary Gland Branching Involved In Thelarche Branch Elongation Involved In Mammary Gland Duct Branching Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Connective Tissue Development Langerhans Cell Differentiation Negative Regulation Of Biomineral Tissue Development Regulation Of Enamel Mineralization Lens Fiber Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hypoxia Cellular Response To Ionizing Radiation Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Mononuclear Cell Migration Odontoblast Differentiation Stem Cell Proliferation Extracellular Matrix Assembly Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Liver Regeneration Cellular Response To Virus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Extracellular Matrix Assembly Response To Salt Positive Regulation Of Mesenchymal Stem Cell Proliferation Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vasculature Development Positive Regulation Of Receptor Signaling Pathway Via STAT Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cellular Response To Acetaldehyde Cellular Response To Insulin-like Growth Factor Stimulus Embryonic Liver Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Primary MiRNA Processing Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation	MAPK Cascade Neuron Migration Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Heart Rate By Hormone Protein Targeting Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Signal Transduction Regulation Of Mitotic Cell Cycle Intracellular Protein Localization Substantia Nigra Development Hippocampus Development Cerebral Cortex Development Intracellular Potassium Ion Homeostasis Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Protein Localization To Nucleus Cellular Response To Heat Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Membrane Repolarization Protein Localization To Endoplasmic Reticulum Protein K11-linked Ubiquitination Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Pathways		Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions ECM proteoglycans SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Transcriptional regulation of white adipocyte differentiation UCH proteinases Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF TGFBR3 regulates TGF-beta signaling	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Hyaluronidase (ovine) Terazosin Hyaluronidase (human recombinant) Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Hyaluronidase	Fusicoccin Phenethyl Isothiocyanate
Diseases		Graft-versus-host disease Allograft rejection Camurati-Engelmann disease; Progressive diaphyseal dysplasia	Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Colorectal cancer ( 24836286 27145994) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 28714974 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Platelet count ( 32888494) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30578418) Type 2 diabetes ( 31049640)	Atrial fibrillation ( 30061737) Bevacizumab-induced composite toxicity (either hypertension or proteinuria) ( 34616010) High light scatter reticulocyte percentage of red cells ( 32888494) Left ventricular mass to end-diastolic volume ratio (MTAG) ( 33495596) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Reaction time ( 29844566) Schizophrenia ( 28991256 30285260)
Interacting Genes		99 interacting genes: ACVRL1 ADAMTSL4 AGR3 ANGPTL4 APC APP AURKA AXIN2 BCAS3 BCL10 BGN BLID BMP2 BMP3 BMPR1A BUB1 CATSPER1 CCDC33 CCL3 CCL5 CCN2 CDKN2A CFTR COL2A1 CST6 CYSRT1 DAXX DCN DIRAS3 DLC1 DPT EGFR EIF3I ENG ERBB2 FBXW7 FCHO1 FCN1 FKBP1A FMOD FNTA GREB1 HOXA1 HOXC6 ITGAV ITGB6 ITGB8 KLK5 KLK7 KLK9 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP4-11 LAMTOR5 LCE1A LCE1C LCE1D LCE1F LCE2B LCE2C LCE3A LCE3B LCE3D LCE5A LPXN LTBP1 LTBP3 LTBP4 MCC MEOX2 MLH3 MMP2 MTA3 NSD3 P4HB PDGFRL PDLIM2 POU4F2 PRSS50 PSMC3IP PZP RAPGEF3 SCGB3A1 SDC2 SNAI1 SPARC ST14 TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 THRSP TLR2 UBC VASN VTN YWHAE	148 interacting genes: ABL1 ACD AKAP13 AKAP9 ANKHD1-EIF4EBP3 ANKZF1 ARHGEF2 ARHGEF28 ATP6V0B ATXN1 BAD BCR BEX3 CALM1 CAP2 CASK CASP3 CCDC125 CCR9 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP131 CEP95 CGNL1 CHAF1A CHST11 CYSLTR2 DDX54 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FGF12 FHL1 FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GSTM3 GTF2B HDAC4 HDAC5 HIVEP2 HNRNPC HSF1 HSP90AA1 HSPB1 IGF1R IL7R ING1 IRAG2 IRS1 IRS2 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KLC4 KRT18 LCOR LCP2 MAGEB4 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MARK2P21 MCM10 MDM4 METAP2 MSL2 MST1R MT-CO2 MYH10 NAF1 NCAM2 NCOR2 NDEL1 NEDD4L NIN PAPOLA PARD3B PIMREG PNLIP POT1 PRC1 PRDX6 PRKCG RAB11FIP2 RAF1 RAP1GAP2 RASAL3 RASGRF1 RBIS RBM14 REM1 RGS3 RIN1 RIPK2 RPA2 RPGR RXFP3 SAMSN1 SLC8A1 SLC8A2 SLC8A3 SMAGP SNAPIN SNCA SNF8 SORBS2 SRC SYN2 TAF7 TAFAZZIN TBC1D3F TBP TCEANC TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 TTC3 UBE3A USP43 VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAZ ZC3HC1 ZNF839
Entrez ID		7040	7531
HPRD ID		01821	05457
Ensembl ID		ENSG00000105329	ENSG00000108953
Uniprot IDs		A0A499FJK2 P01137	P62258 V9HW98
PDB IDs		1KLA 1KLC 1KLD 3KFD 4KV5 5FFO 5VQP 6OM2 6P7J 7Y1R 7Y1T 8UDZ 8VSC 8VSD 9FDY 9FKP	2BR9 3UAL 3UBW 6EIH 7C8E 7V9B 8DGM 8DGN 8DGP 8DP5 8Q1S
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Binding Tissue Development Epidermis Development Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Developmental Process Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Extracellular Matrix Cell Surface Receptor Signaling Pathway Keratinization Endocardial Cushion Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Positive Regulation Of SMAD Protein Signal Transduction Extracellular Space Regulation Of Cell Migration Cardiac Epithelial To Mesenchymal Transition Anatomical Structure Morphogenesis Cellular Response To Growth Factor Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Extracellular Matrix Organization Extracellular Structure Organization Activin Binding Positive Regulation Of Cell Migration Glycosaminoglycan Binding Regulation Of Multicellular Organismal Process Regulation Of Epithelial Cell Proliferation Response To Growth Factor Cell Surface Positive Regulation Of Cell Motility Regulation Of SMAD Protein Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Locomotion Extracellular Region Regulation Of Programmed Cell Death Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Roof Of Mouth Development Extracellular Matrix Binding Regulation Of Apoptotic Process Regulation Of Signal Transduction Epithelial To Mesenchymal Transition Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis	Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Signaling Identical Protein Binding Regulation Of Signal Transduction Regulation Of Protein Modification Process Regulation Of Biological Quality Transmembrane Transporter Binding Positive Regulation Of Metabolic Process Cytoplasm Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Membrane Potential Cytosol Negative Regulation Of Signal Transduction Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction MAPK Cascade Nucleus Regulation Of Rho Protein Signal Transduction Intracellular Signaling Cassette MAP Kinase Kinase Kinase Activity Regulation Of Catalytic Activity Cellular Response To Hydrogen Peroxide Protein Kinase Binding Axon Postsynaptic Density Calcium:sodium Antiporter Activity Response To Hydrogen Peroxide Protein-containing Complex Protein Kinase C Binding Cellular Response To Chemical Stress Protein Domain Specific Binding Regulation Of Primary Metabolic Process Cellular Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Transferase Activity Enzyme Binding Perinuclear Region Of Cytoplasm
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