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ADAM17 and TGFA
Number of citations of the paper that reports this interaction (PubMedID
18930083
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
ADAM17
TGFA
Description
ADAM metallopeptidase domain 17
transforming growth factor alpha
Image
GO Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Endoplasmic Reticulum Lumen
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Surface
Actin Cytoskeleton
Membrane
Apical Plasma Membrane
Ruffle Membrane
Membrane Raft
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Membrane
Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Basolateral Plasma Membrane
Clathrin-coated Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Notch Binding
Interleukin-6 Receptor Binding
Integrin Binding
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Hydrolase Activity
SH3 Domain Binding
Cytokine Binding
PDZ Domain Binding
Tumor Necrosis Factor Binding
Metal Ion Binding
Metallodipeptidase Activity
Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Signaling Receptor Binding
Epidermal Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
Receptor Ligand Activity
Biological Process
Response To Hypoxia
Neutrophil Mediated Immunity
Germinal Center Formation
Production Of Molecular Mediator Involved In Inflammatory Response
Positive Regulation Of Leukocyte Chemotaxis
Proteolysis
Membrane Protein Ectodomain Proteolysis
Cell Adhesion
Epidermal Growth Factor Receptor Signaling Pathway
Notch Signaling Pathway
Notch Receptor Processing
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Positive Regulation Of Signal Transduction
Positive Regulation Of T Cell Chemotaxis
Negative Regulation Of Neuron Projection Development
Protein Processing
Signal Release
B Cell Differentiation
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Lipopolysaccharide
Positive Regulation Of Chemokine Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Mast Cell Apoptotic Process
T Cell Differentiation In Thymus
Cell Adhesion Mediated By Integrin
Wound Healing, Spreading Of Epidermal Cells
Amyloid Precursor Protein Catabolic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Spleen Development
Regulation Of Axon Regeneration
Cell Motility
Defense Response To Gram-positive Bacterium
Cellular Response To High Density Lipoprotein Particle Stimulus
Commissural Neuron Axon Guidance
Negative Regulation Of Cold-induced Thermogenesis
Cytokine Precursor Processing
Signaling Receptor Ligand Precursor Processing
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Neuron Migration
Angiogenesis
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Intracellular Signal Transduction
ERBB2-EGFR Signaling Pathway
Positive Regulation Of MAPK Cascade
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Cell Division
Mammary Gland Alveolus Development
Hepatocyte Proliferation
Pathways
Nuclear signaling by ERBB4
Collagen degradation
Signaling by EGFR
Regulated proteolysis of p75NTR
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Release of Hh-Np from the secreting cell
TNF signaling
CD163 mediating an anti-inflammatory response
Growth hormone receptor signaling
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
COPII-mediated vesicle transport
EGFR interacts with phospholipase C-gamma
Constitutive Signaling by Aberrant PI3K in Cancer
Inhibition of Signaling by Overexpressed EGFR
RAF/MAP kinase cascade
Cargo concentration in the ER
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Extra-nuclear estrogen signaling
Estrogen-dependent gene expression
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Developmental Lineage of Mammary Gland Luminal Epithelial Cells
Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs
(3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiol
3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol
4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
(2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE
methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate
(1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid
N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan
(3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
Diseases
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
Gastric cancer
GWAS
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Offspring birth weight (
31043758
)
Acne (severe) (
24927181
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Hair shape (
29220522
)
Hand grip strength (
29691431
29313844
)
Heel bone mineral density (
30598549
)
Hip minimal joint space width (
27701424
)
Longevity (
20834067
)
Low hand grip strength (60 years and older) (EWGSOP) (
33510174
)
Low hand grip strength (60 years and older) (FNIH) (
33510174
)
Neutrophil count (
21507922
)
Obesity-related traits (
23251661
)
Osteoarthritis (
30664745
)
Pulse pressure in young-onset hypertension (
24892410
)
Response to citalopram or escitalopram in depression (
27622933
)
Response to esketamine in treatment resistant depression (
32724131
)
Severe progression in rheumatoid arthritis (
29065906
)
Superior frontal gyrus grey matter volume (
25335168
)
Interacting Genes
13 interacting genes:
DLG1
ERBB4
FHL2
MAD2L1
MAD2L2
NOTCH1
PTPN3
SH3D19
TGFA
TIMP3
TNF
TNFRSF1A
TNFSF11
17 interacting genes:
ADAM10
ADAM17
EGFR
ELANE
ERBB2
ERBB4
GORASP1
GORASP2
LEPROTL1
MAGI2
MAGI3
NKD2
RHBDD1
RHBDF1
SDCBP
SGTA
SNTA1
Entrez ID
6868
7039
HPRD ID
04703
07522
Ensembl ID
ENSG00000151694
ENSG00000163235
Uniprot IDs
B2RNB2
P78536
E7EPT6
F8VNR3
P01135
PDB IDs
1BKC
1ZXC
2A8H
2DDF
2FV5
2FV9
2I47
2M2F
2OI0
3B92
3CKI
3E8R
3EDZ
3EWJ
3G42
3KMC
3KME
3L0T
3L0V
3LE9
3LEA
3LGP
3O64
8CQY
8SNL
8SNN
8SNO
9E6K
1GK5
1MOX
1YUF
1YUG
2TGF
3E50
3TGF
4TGF
5KN5
7SZ5
7SZ7
Enriched GO Terms of Interacting Partners
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Regulation Of Membrane Protein Ectodomain Proteolysis
Epithelial Cell Proliferation
Mammary Gland Alveolus Development
Regulation Of Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Signal Transduction
Negative Regulation Of Extracellular Matrix Organization
Regulation Of Mitotic Cell Cycle
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Mitotic Nuclear Division
Negative Regulation Of Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Nuclear Division
Regulation Of Endothelial Cell Differentiation
Negative Regulation Of Extracellular Matrix Constituent Secretion
Negative Regulation Of Cell Cycle
Regulation Of MAPK Cascade
Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Catabolic Process
Positive Regulation Of Fever Generation
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Primary Metabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Extracellular Matrix Constituent Secretion
Positive Regulation Of Apoptotic Process Involved In Development
Regulation Of Fever Generation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of MAPK Cascade
Negative Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Extracellular Matrix Organization
Intracellular Signal Transduction
Protein Localization To Cell Periphery
Establishment Of Centrosome Localization
Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Cell Surface Receptor Signaling Pathway Via STAT
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Heat Generation
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cell-cell Adhesion
Regulation Of Macromolecule Metabolic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Localization Within Membrane
Positive Regulation Of Growth
Positive Regulation Of Cell Growth
Cellular Localization
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Endopeptidase Activity
Establishment Of Protein Localization To Membrane
ERBB2 Signaling Pathway
Epidermal Growth Factor Receptor Activity
Positive Regulation Of Phosphorylation
Membrane
Membrane Protein Proteolysis
Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Population Proliferation
ERBB2-ERBB4 Signaling Pathway
Positive Regulation Of Phosphate Metabolic Process
Growth Factor Binding
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Cell Population Proliferation
Regulation Of Growth
Transmembrane Receptor Protein Tyrosine Kinase Activity
Response To Epidermal Growth Factor
Regulation Of Cell Migration
Regulation Of Signal Transduction
Golgi Membrane
Regulation Of Protein Catabolic Process
Metallodipeptidase Activity
ERBB2-EGFR Signaling Pathway
Regulation Of Cell Motility
Regulation Of Cell Growth
ERBB4 Signaling Pathway
Basal Plasma Membrane
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Locomotion
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Phosphorylation
Regulation Of ERBB Signaling Pathway
Positive Regulation Of MAPK Cascade
Neuromuscular Junction
Positive Regulation Of Protein Phosphorylation
ATPase Binding
Regulation Of Cell Communication
Regulation Of Signaling
Basolateral Plasma Membrane
Positive Regulation Of T Cell Chemotaxis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of T Cell Chemotaxis
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Tagcloud (Intersection)
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