ADAM17 and DLG1

Number of citations of the paper that reports this interaction (PMID 12668732)
11

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ADAM17	DLG1
Gene Name		ADAM metallopeptidase domain 17	discs, large homolog 1 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Actin Cytoskeleton Membrane Apical Plasma Membrane Ruffle Membrane Membrane Raft	Immunological Synapse Basal Lamina Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Tight Junction Ionotropic Glutamate Receptor Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Lateral Loop Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex
	Molecular Function	Metalloendopeptidase Activity Notch Binding Interleukin-6 Receptor Binding Integrin Binding Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding PDZ Domain Binding	Guanylate Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Protein Kinase Binding Phosphatase Binding Mitogen-activated Protein Kinase Kinase Binding Protein Complex Scaffold Ionotropic Glutamate Receptor Binding Ion Channel Binding L27 Domain Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Neutrophil Mediated Immunity Germinal Center Formation Positive Regulation Of Leukocyte Chemotaxis Proteolysis Membrane Protein Ectodomain Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Cell Proliferation Positive Regulation Of T Cell Chemotaxis Extracellular Matrix Disassembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Collagen Catabolic Process Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Response To Lipopolysaccharide Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Regulation Of Mast Cell Apoptotic Process T Cell Differentiation In Thymus Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Response To Drug Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Neurotrophin TRK Receptor Signaling Pathway Spleen Development Cell Motility PMA-inducible Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cellular Component Movement Response To High Density Lipoprotein Particle JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Apoptotic Signaling Pathway	Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye T Cell Cytokine Production Actin Filament Organization Mitotic Cell Cycle Checkpoint Establishment Or Maintenance Of Cell Polarity Synaptic Transmission Nervous System Development Axon Guidance Positive Regulation Of Cell Proliferation Viral Process Dephosphorylation Single Organismal Cell-cell Adhesion Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Membrane Raft Organization Regulation Of Myelination Activation Of Protein Kinase Activity T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Positive Regulation Of Potassium Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Nucleotide Phosphorylation Reproductive Structure Development Embryonic Skeletal System Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Kinase B Signaling Hard Palate Development Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor Localization To Synapse Regulation Of Sodium Ion Transmembrane Transport
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Hedgehog ligand biogenesis TNF signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Death Receptor Signalling Signaling by EGFRvIII in Cancer Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Release of Hh-Np from the secreting cell Signaling by NOTCH1 Programmed Cell Death Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Regulated proteolysis of p75NTR Signalling by NGF Collagen degradation Signaling by NOTCH Processing-defective Hh variants abrogate ligand secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Cytokine Signaling in Immune system p75 NTR receptor-mediated signalling Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 Signaling by EGFR in Cancer Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants Extrinsic Pathway Growth hormone receptor signaling	Axon guidance Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11	72 interactors: ACTA1 ACTN2 ADAM17 ADRB1 AKAP5 ATP2B2 ATP2B4 BAI1 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GPR124 GPR125 GRIA1 GRIK2 GRIN2A GRIN2B GUCY1A2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PARK2 PAX6 PBK PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TJAP1 UBE3A WAS WNT3A
Entrez ID		6868	1739
HPRD ID		04703	03007
Ensembl ID		ENSG00000151694	ENSG00000075711
Uniprot IDs		B2RNB2 P78536	B4DF78 Q12959
PDB IDs		1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64	1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Proteolysis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gland Development Positive Regulation Of Phosphorylation Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Response To Tumor Necrosis Factor Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of APC-Cdc20 Complex Activity Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Mammary Gland Lobule Development Mammary Gland Alveolus Development Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Kinase Activity Positive Regulation Of JAK-STAT Cascade Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Cycle Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Transferase Activity Regulation Of Cell Division Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Localization Positive Regulation Of Fever Generation Activation Of Protein Kinase Activity	Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Metal Ion Transport Regulation Of Membrane Potential Neurological System Process Regulation Of Signaling Cation Transport Ion Transport Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Synaptic Plasticity Nervous System Development Response To Wounding Cation Transmembrane Transport Transport Ion Transmembrane Transport Regulation Of Cellular Localization Regulation Of Phosphorus Metabolic Process Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Response To Abiotic Stimulus Membrane Depolarization Regulation Of Cellular Process Regulation Of Signal Transduction Action Potential Monovalent Inorganic Cation Transport Response To Stimulus Potassium Ion Import System Development Transmembrane Transport Behavior Cellular Process Transmission Of Nerve Impulse Wound Healing Cellular Response To Stimulus Neuronal Action Potential Positive Regulation Of Transport Regulation Of Heart Contraction Cellular Localization Anatomical Structure Development Membrane Hyperpolarization Protein Homooligomerization Regulation Of Cellular Component Movement Regulation Of Body Fluid Levels Central Nervous System Development Neuromuscular Process
Tagcloud ?		anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally transmembrane	adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly
Tagcloud (Difference) ?		anchored apma arguing betacellulin bzatp cd23 cd62 chimeras constitutive convertase cytoplasmic disintegrin dispensable domain ectodomain influences influx ionomycin metalloprotease metalloproteinase motif negatively pro retention shedding tgfalpha translationally transmembrane	adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly
Tagcloud (Intersection) ?