ADAM17 and NOTCH1

  • Number of citations of the paper that reports this interaction (PMID 9620803)
  • 343
  • Data Source:
  • HPRD (in vitro, in vivo)

ADAM17

NOTCH1

Gene Name ADAM metallopeptidase domain 17 notch 1
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 14 interactors: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11 56 interactors: ADAM17 AKT1 APBA1 BLOC1S1 CACNA1A CAMK4 CBL CNTN1 CTNNB1 DLL1 DLL4 DTX1 DTX2 EGFL7 EP300 FBXW7 FURIN GFI1B GSK3B ILK ITCH JAG1 JAG2 KAT2A KAT2B LCK LEF1 LFNG MAML1 MAML2 MAML3 MDM2 MEF2C MFNG NFKB1 NOV NUMB NUMBL PIK3CG POFUT1 PSEN1 PSEN2 RBP3 RBPJ REL RELA RUNX3 SMAD3 SNAI1 SNW1 USP12 WDR12 WWP1 XIAP XRCC6 YY1
Entrez ID 6868 4851
HPRD ID 04703 01827
Ensembl ID ENSG00000151694 ENSG00000148400
Uniprot IDs B2RNB2 P78536 P46531
PDB IDs 1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64 1PB5 1TOZ 1YYH 2F8X 2F8Y 2HE0 2VJ3 3ETO 3I08 3L95 3NBN 3V79
Enriched GO Terms of Interacting Partners?
Tagcloud ?
anchored  apma  arguing  betacellulin  bzatp  cd23  cd62  chimeras  constitutive  convertase  cytoplasmic  disintegrin  dispensable  domain  ectodomain  influences  influx  ionomycin  metalloprotease  metalloproteinase  motif  negatively  pro  retention  shedding  tgfalpha  translationally  transmembrane 
a23187  alpha1  antitrypsin  biologically  carboxyl  cleaved  convertase  convertases  decisions  dibasic  digestion  disagree  exists  extend  fate  furin  heterodimeric  invertebrates  ionophore  lovo  nearby  pdx  processed  processing  proteolytic  rqrr  takes  vertebrates 
Tagcloud (Difference) ?
anchored  apma  arguing  betacellulin  bzatp  cd23  cd62  chimeras  constitutive  cytoplasmic  disintegrin  dispensable  domain  ectodomain  influences  influx  ionomycin  metalloprotease  metalloproteinase  motif  negatively  pro  retention  shedding  tgfalpha  translationally  transmembrane 
a23187  alpha1  antitrypsin  biologically  carboxyl  cleaved  convertases  decisions  dibasic  digestion  disagree  exists  extend  fate  furin  heterodimeric  invertebrates  ionophore  lovo  nearby  pdx  processed  processing  proteolytic  rqrr  takes  vertebrates 
Tagcloud (Intersection) ?
convertase