HMGN2 and RPS6KA3

Number of citations of the paper that reports this interaction (PMID 11438671)
28

Data Source:
HPRD (in vitro)

		HMGN2	RPS6KA3
Gene Name		high mobility group nucleosomal binding domain 2	ribosomal protein S6 kinase, 90kDa, polypeptide 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Nucleoplasm Cytosol
	Molecular Function	Nucleosomal DNA Binding Poly(A) RNA Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process		Skeletal System Development Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Cell Cycle Signal Transduction Synaptic Transmission Axon Guidance Central Nervous System Development Positive Regulation Of Cell Growth Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways			Signaling by GPCR CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ERK/MAPK targets Post NMDA receptor activation events Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transmission across Chemical Synapses Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: EP300 HMGN1 KAT2B PRKACA PRKCA RPS6KA3 TERF2 UBE2I	32 interactors: ATP5J BAD BARX1 CREB1 CREBBP EIF3C ESR1 FGF2 FGFR1 GRIN1 GRIN2D H2AFX HIST1H3A HIST3H3 HMGN1 HMGN2 HTR2A KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS STK11 YBX1
Entrez ID		3151	6197
HPRD ID		01230	02092
Ensembl ID			ENSG00000177189
Uniprot IDs		P05204	B7ZB17 F5GYC4 P51812
PDB IDs			4D9T 4D9U 4JG6 4JG7 4JG8
Enriched GO Terms of Interacting Partners?		Cell Cycle Chromatin Organization Positive Regulation Of Dense Core Granule Biogenesis Chromosome Organization Positive Regulation Of Metabolic Process N-terminal Peptidyl-lysine Acetylation Histone H3-T6 Phosphorylation Negative Regulation Of Cellular Metabolic Process Chromatin Modification Positive Regulation Of Cellular Metabolic Process Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Cycle Histone Modification Peptidyl-amino Acid Modification Organelle Organization N-terminal Protein Amino Acid Acetylation Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Cell Cycle Process Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Glucose Transport Regulation Of Platelet Aggregation Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Negative Regulation Of Biosynthetic Process Regulation Of Rhodopsin Mediated Signaling Pathway N-terminal Protein Amino Acid Modification Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of Protein Kinase Activity Activation Of Adenylate Cyclase Activity Mitotic Cell Cycle Process Regulation Of Cardiac Muscle Hypertrophy Neurotrophin Signaling Pathway Regulation Of Platelet Activation Rhodopsin Mediated Signaling Pathway Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Innate Immune Response Cell Death Death Regulation Of Signaling Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Phospholipase C Activity Response To Organic Substance Positive Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Biosynthetic Process Immune Response Insulin Receptor Signaling Pathway Response To Growth Factor Regulation Of Signal Transduction Anatomical Structure Morphogenesis Response To Peptide Immune System Process Cell Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Response To Stress Regulation Of Metabolic Process Response To Hormone Cellular Response To Organic Substance Apoptotic Process Cellular Response To Insulin Stimulus Programmed Cell Death
Tagcloud ?		bioactivities characterize count downregulated exerts gfp healing hmgn1 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound	aberrations applying arid2 axin1 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Difference) ?		bioactivities characterize count downregulated exerts gfp healing hmgn1 hmgn5 hmgns infect ki lentivirus markedly migration mobility nude os osteosarcoma pcna recombinant relatively relevance remain sao2 subcutaneous u2 volumes wound	aberrations applying arid2 axin1 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs
Tagcloud (Intersection) ?