HMGN2 and TERF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (cross-linking study, two hybrid)

		HMGN2	TERF2
Description		high mobility group nucleosomal binding domain 2	telomeric repeat binding factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Space Nucleus Cytoplasm	Chromosome, Telomeric Region Telomere Cap Complex Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nuclear Body Axon Shelterin Complex
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding Nucleosomal DNA Binding	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Chromatin Organization Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Telomere Maintenance In Utero Embryonic Development RNA-templated DNA Biosynthetic Process Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Rosacea symptom severity ( 29771307)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Daytime nap ( 33568662) Leukocyte telomere length ( 32109421) Logical memory (delayed recall) in normal cognition ( 29274321) Pulse pressure ( 30578418)
Interacting Genes		14 interacting genes: CEBPA EP300 HMGN1 HPF1 KAT2B MTNR1A PARP1 PRKACA PRKCA RPS6KA3 SRPK2 TERF2 UBC UBE2I	58 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18
Entrez ID		3151	7014
HPRD ID		01230	03610
Ensembl ID		ENSG00000198830	ENSG00000132604
Uniprot IDs		P05204	Q15554
PDB IDs			1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67 7C5D
Enriched GO Terms of Interacting Partners?		Protein Modification Process Nucleoplasm Protein Localization To Chromosome Regulation Of ATP Metabolic Process Chromatin Organization Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Chromatin Binding N-terminal Peptidyl-lysine Acetylation Response To Hormone Protein Localization To Chromatin Chromatin Remodeling Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Regulation Of Glycolytic Process Regulation Of Gluconeogenesis Macromolecule Metabolic Process Transferase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Response To Stress Nucleus Internal Protein Amino Acid Acetylation STAT Family Protein Binding Cellular Response To Parathyroid Hormone Stimulus TOR Signaling N-terminal Protein Amino Acid Acetylation Positive Regulation Of Metabolic Process Peptidyl-lysine Acetylation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Learning Or Memory Modification-dependent Protein Catabolic Process Response To Parathyroid Hormone Regulation Of Glucose Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Peptide Hormone Protein Poly-ADP-ribosylation Carbohydrate Biosynthetic Process Cognition Protein Localization To Organelle Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Acetyltransferase Activity	Nucleoplasm Nucleus DNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Damage Response Chromosome, Telomeric Region DNA Recombination Telomere Maintenance Chromatin Organization Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Organization DNA Repair Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Recombinational Repair Cellular Response To Stress Regulation Of Primary Metabolic Process DNA Binding Regulation Of DNA Metabolic Process Double-strand Break Repair Negative Regulation Of Metabolic Process Nuclear Speck RNA Binding DNA Geometric Change Bubble DNA Binding Chromosome Organization Telomeric DNA Binding Negative Regulation Of RNA Metabolic Process Damaged DNA Binding Nuclear Telomere Cap Complex 7SK SnRNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Cellular Response To Ionizing Radiation Negative Regulation Of Macromolecule Biosynthetic Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Metabolic Process Cytoplasm Regulation Of DNA Recombination Response To Ionizing Radiation Nucleosomal DNA Binding Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Forked DNA-dependent Helicase Activity
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