COBLL1

Description		cordon-bleu WH2 repeat protein like 1
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GO Annotations	Cellular Component	Cell Cortex Membrane Extracellular Exosome
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Cadherin Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Blood glucose levels ( 31928498) Body composition traits ( 30026463) Body fat percentage ( 26833246) Body mass index ( 25673413 26426971 29381148) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) circulating leptin levels ( 26833098 32917775) circulating leptin levels adjusted for BMI ( 26833098 32917775) Circulating leptin levels or type 2 diabetes ( 32341051) Fasting blood insulin (BMI interaction) ( 22581228) Fasting blood insulin adjusted for BMI ( 25625282) Fasting insulin ( 34059833) Glomerular filtration rate in chronic kidney disease ( 26420894) Glycine levels ( 30837465) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Heschl's gyrus morphology ( 25130324) High density lipoprotein cholesterol levels ( 31928498 33339817) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin concentration ( 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 32888494) Response to statin therapy ( 20339536) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sexual dimorphism in anthropometric traits ( 23754948) Systolic blood pressure ( 30578418) Triglyceride levels ( 30698716 31928498 32154731 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 20686565) Two-hour glucose ( 34059833) Type 2 diabetes ( 30054458 30297969 30718926 31118516) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 23563607 25673412 28552196) Waist-to-hip ratio adjusted for BMI ( 26426971 28552196 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		2 interacting genes: TMBIM6 USP7
Entrez ID		22837
HPRD ID		10844
Ensembl ID		ENSG00000082438
Uniprot IDs		A0A0D9SG04 A0A0X1KG75 B7Z2P5 Q53SF7
PDB IDs		2DAJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcium Ion Transport Into Cytosol Endoribonuclease Inhibitor Activity Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Cellular Localization Monoubiquitinated Protein Deubiquitination IRE1-mediated Unfolded Protein Response Negative Regulation Of Immunoglobulin Production DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Cellular Response To Unfolded Protein Negative Regulation Of Cellular Response To Hypoxia Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Gluconeogenesis Regulation Of Telomere Capping K48-linked Deubiquitinase Activity Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cellular Response To Hypoxia Endoplasmic Reticulum Calcium Ion Homeostasis Deubiquitinase Activity Negative Regulation Of RNA Splicing Cellular Response To Topologically Incorrect Protein Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Gene Expression Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Calcium Ion Transport Nucleotide-excision Repair Regulation Of Gluconeogenesis Negative Regulation Of Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of TORC1 Signaling Negative Regulation Of Proteasomal Protein Catabolic Process
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