HJV

Description		hemojuvelin BMP co-receptor
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Membrane BMP Receptor Complex Side Of Membrane Plasma Membrane Protein Complex HFE-transferrin Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Coreceptor Activity BMP Binding BMP Receptor Activity Transferrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Protein Autoprocessing BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To BMP Stimulus
Pathways		Netrin-1 signaling
Drugs
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS
Interacting Genes		1 interacting genes: TMBIM6
Entrez ID		148738
HPRD ID		10521
Ensembl ID		ENSG00000168509
Uniprot IDs		A8K466 Q6ZVN8
PDB IDs		4UI1 6Z3L
Enriched GO Terms of Interacting Partners?		Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Endoribonuclease Inhibitor Activity Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Cellular Response To Unfolded Protein Regulation Of Cellular Response To Hypoxia Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Response To L-glutamate Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cytosolic Calcium Ion Concentration IRE1-mediated Unfolded Protein Response Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Immunoglobulin Production Cellular Response To Topologically Incorrect Protein Negative Regulation Of RNA Splicing Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Calcium Ion Transport Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Immunoglobulin Production Response To Unfolded Protein Calcium Channel Activity Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Monoatomic Ion Transport Response To Amino Acid Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Splicing Intracellular Calcium Ion Homeostasis Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Signaling Pathway Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Autophagy
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