UGT2B11 and ASPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UGT2B11	ASPH
Description		UDP glucuronosyltransferase family 2 member B11	aspartate beta-hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Protein Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity
	Biological Process	Xenobiotic Metabolic Process Estrogen Metabolic Process	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization
Pathways		Glucuronidation Aspirin ADME	Stimuli-sensing channels Ion homeostasis Protein hydroxylation
Drugs			Aspartic acid
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Metabolite levels ( 23823483) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102)	Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)
Interacting Genes		2 interacting genes: ASPH TMBIM6	73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16
Entrez ID		10720	444
HPRD ID		04345	08996
Ensembl ID		ENSG00000213759	ENSG00000198363
Uniprot IDs		O75310	B4DQ07 B7ZM96 G3XAN5 Q12797
PDB IDs			5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9
Enriched GO Terms of Interacting Partners?		Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-aspartic Acid 3-dioxygenase Activity Intracellular Calcium Ion Homeostasis Regulation Of Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Endoribonuclease Inhibitor Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Activation Of Store-operated Calcium Channel Activity Intracellular Monoatomic Ion Homeostasis Regulation Of Metal Ion Transport Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Store-operated Calcium Channel Activity Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Intracellular Chemical Homeostasis Regulation Of Cellular Localization Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Metal Ion Transport IRE1-mediated Unfolded Protein Response Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Negative Regulation Of Immunoglobulin Production Negative Regulation Of Cellular Response To Hypoxia Positive Regulation Of Calcium Ion Transport Into Cytosol Inorganic Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Detection Of Calcium Ion Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Unfolded Protein Response To L-glutamate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Chemical Homeostasis Positive Regulation Of Cation Channel Activity	Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport
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