DOC2B and UNC13B

Number of citations of the paper that reports this interaction (PubMedID 10488064)
0

Data Source:
HPRD (in vivo, two hybrid)

		DOC2B	UNC13B
Description		double C2 domain beta	unc-13 homolog B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane SNARE Complex Synapse Presynapse	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Terminal Bouton Synapse Presynaptic Active Zone
	Molecular Function	Calcium Ion Binding Calcium-dependent Phospholipid Binding Syntaxin Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Zinc Ion Binding Syntaxin-1 Binding Diacylglycerol Binding GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Chemical Synaptic Transmission Intracellular Protein Localization Positive Regulation Of Vesicle Fusion Positive Regulation Of Insulin Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion	Exocytosis Chemical Synaptic Transmission Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Secretion Acrosomal Vesicle Exocytosis Dense Core Granule Priming Cellular Response To Glucose Stimulus Positive Regulation Of Inhibitory Postsynaptic Potential Neuronal Dense Core Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle
Drugs
Diseases
GWAS			Parkinson's disease ( 21812969)
Interacting Genes		3 interacting genes: DYNLT1 STXBP1 UNC13B	12 interacting genes: CFAP298 CLK1 DOC2A DOC2B PDCL2 RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1
Entrez ID		8447	10497
HPRD ID		05196	05785
Ensembl ID		ENSG00000272636	ENSG00000198722
Uniprot IDs		Q14184	A0A1B0GUS7 A0A1B0GVW8 O14795
PDB IDs
Enriched GO Terms of Interacting Partners?		Dense Core Granule Exocytosis Neuronal Dense Core Vesicle Exocytosis Regulation Of Synaptic Vesicle Priming Secretory Granule Localization Establishment Of Organelle Localization Syntaxin-1 Binding Synaptic Vesicle Priming Calcium-ion Regulated Exocytosis Vesicle Docking Involved In Exocytosis Organelle Localization Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Positive Regulation Of Transport Regulated Exocytosis Establishment Of Vesicle Localization Vesicle Localization Positive Regulation Of Vesicle Docking Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of Synaptic Vesicle Priming Intracellular Transport Of Viral Protein In Host Cell Dense Core Granule Priming Exocytosis Axon Target Recognition Regulation Of Acrosomal Vesicle Exocytosis Extrinsic Component Of Presynaptic Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Glutamate Secretion, Neurotransmission Negative Regulation Of Synaptic Transmission, GABAergic Establishment Of Localization In Cell Regulation Of Transport Platelet Degranulation Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Secretion By Cell Acrosomal Vesicle Exocytosis Chemical Synaptic Transmission Positive Regulation Of Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Trans-synaptic Signaling Synaptic Signaling Modulation Of Inhibitory Postsynaptic Potential Synaptic Vesicle Maturation Intracellular Transport Of Virus Secretion By Cell Calcium Ion-regulated Exocytosis Of Neurotransmitter Host Cell Secretory Vesicle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Glutamate Secretion	Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Secretion By Cell Vesicle-mediated Transport In Synapse Calcium-ion Regulated Exocytosis Neurotransmitter Transport Regulated Exocytosis Spontaneous Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Regulated Secretory Pathway SNARE Complex Positive Regulation Of Regulated Secretory Pathway Synaptic Vesicle Docking Signal Release Vesicle Docking Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Exocytosis Vesicle-mediated Transport Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Membrane Docking Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Vesicle-mediated Transport Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Positive Regulation Of Secretion By Cell Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Secretion Regulation Of Secretion Regulation Of Vesicle Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Membrane Fusion Modulation Of Excitatory Postsynaptic Potential SNARE Binding Presynapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Establishment Of Localization In Cell Regulation Of Synaptic Vesicle Priming Regulation Of Neurotransmitter Secretion Vesicle Fusion Organelle Membrane Fusion Synaptic Vesicle Membrane Organization
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