DOC2B and UNC13B

Number of citations of the paper that reports this interaction (PMID 9195900)
27

Data Source:
HPRD (in vivo, two hybrid)

		DOC2B	UNC13B
Gene Name		double C2-like domains, beta	unc-13 homolog B (C. elegans)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Synaptic Vesicle SNARE Complex	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Junction Neuromuscular Junction Terminal Bouton Presynaptic Active Zone
	Molecular Function	Transporter Activity Calcium-dependent Phospholipid Binding	Signal Transducer Activity Receptor Activity Protein Binding Diacylglycerol Binding Metal Ion Binding
	Biological Process	Protein Localization Positive Regulation Of Vesicle Fusion Positive Regulation Of Insulin Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion-dependent Exocytosis Of Neurotransmitter	Apoptotic Process Signal Transduction Synaptic Transmission Neurotransmitter Secretion Neuromuscular Junction Development Excretion Positive Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Intracellular Signal Transduction Regulation Of Short-term Neuronal Synaptic Plasticity Innervation Positive Regulation Of Inhibitory Postsynaptic Membrane Potential
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Parkinson's disease ( 21812969)
Protein-Protein Interactions		3 interactors: DYNLT1 STXBP1 UNC13B	9 interactors: DOC2A DOC2B RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1
Entrez ID		8447	10497
HPRD ID		05196	05785
Ensembl ID			ENSG00000198722
Uniprot IDs		Q14184	B1AM27 F8W8M9 O14795 Q4LE73
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Priming Establishment Of Organelle Localization Glutamate Secretion Organelle Localization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Transport Acid Secretion Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Regulation Of Neurotransmitter Secretion Vesicle Docking Dicarboxylic Acid Transport Membrane Docking Neurotransmitter Secretion Synaptic Vesicle Transport Regulation Of Neurotransmitter Levels Positive Regulation Of Synaptic Vesicle Priming Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Regulation Of Exocytosis Amino Acid Transport Regulation Of Synaptic Plasticity Neurotransmitter Transport Establishment Of Vesicle Localization Vesicle Localization Positive Regulation Of Synaptic Vesicle Exocytosis Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Positive Regulation Of Secretion Regulation Of Cellular Component Organization Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Intracellular Transport Of Viral Protein In Host Cell Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Axon Target Recognition Regulation Of Protein Complex Assembly Exocytosis Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of SNARE Complex Assembly Nervous System Development Synaptic Vesicle Docking Organic Anion Transport Cellular Localization Synaptic Vesicle Priming Secretion By Cell Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Maturation Regulation Of Inhibitory Postsynaptic Membrane Potential Synaptic Transmission	Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Synaptic Vesicle Exocytosis Neurotransmitter Transport Secretion By Cell Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Secretion Vesicle-mediated Transport Establishment Of Organelle Localization Regulation Of Vesicle-mediated Transport Membrane Fusion Cell-cell Signaling Organelle Localization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Cellular Localization Establishment Of Localization In Cell Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Transmission Vesicle Fusion Cellular Localization Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Organelle Fusion Positive Regulation Of Secretion Vesicle Docking Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Of Neurotransmitter Membrane Docking Transport Intracellular Protein Transport Membrane Depolarization Protein Localization Positive Regulation Of Neurotransmitter Secretion Glutamate Secretion Cellular Protein Localization Protein Transport Vesicle Organization Establishment Of Protein Localization Intracellular Transport Regulation Of Synaptic Vesicle Exocytosis
Tagcloud ?			accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Difference) ?			accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Intersection) ?