SFRP2

Description		secreted frizzled related protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Fibronectin Binding Integrin Binding Enzyme Activator Activity Wnt-protein Binding Receptor Ligand Activity Endopeptidase Activator Activity
	Biological Process	Regulation Of Cell Growth Branching Involved In Blood Vessel Morphogenesis Somitogenesis Neural Tube Closure Chondrocyte Development Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Apoptotic Process Cell-cell Signaling Mesodermal Cell Fate Specification Response To Nutrient Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Xenobiotic Stimulus Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Neural Tube Development Regulation Of Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Cell Adhesion Mediated By Integrin Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Mesodermal Cell Fate Specification Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Development Of Primary Male Sexual Characteristics Digestive Tract Morphogenesis Stem Cell Fate Specification Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Sclerotome Development Negative Regulation Of Dermatome Development Hematopoietic Stem Cell Proliferation Cellular Response To X-ray Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Midbrain Dopaminergic Neuron Differentiation Regulation Of Stem Cell Division
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Drugs
Diseases
GWAS		Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Facial morphology ( 31763980) Macular thickness ( 30535121) Nose morphology ( 29921221 33593615) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		15 interacting genes: BMPR1A BUB1 CDH1 CTNNA1 DBNDD2 DCC EEF1G MLH3 PAX2 PFKM RAD54B SFRP5 SMAD4 WNT1 WNT4
Entrez ID		6423
HPRD ID		16041
Ensembl ID		ENSG00000145423
Uniprot IDs		A0A140VJU3 B3KSM5 Q96HF1
PDB IDs
Enriched GO Terms of Interacting Partners?		Branching Involved In Ureteric Bud Morphogenesis Tube Morphogenesis Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Positive Regulation Of Dermatome Development Negative Regulation Of Neurogenesis Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Nervous System Development Regulation Of Multicellular Organismal Development Cellular Response To Indole-3-methanol Morphogenesis Of A Branching Epithelium Metanephric Tubule Formation Metanephric Mesenchymal Cell Differentiation Morphogenesis Of A Branching Structure Response To Indole-3-methanol Mesendoderm Development Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Cell Differentiation Tissue Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Flotillin Complex Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Kidney Development Axis Specification Neuron Projection Development Gamma-catenin Binding Mesonephros Development Animal Organ Morphogenesis Regionalization Gland Development Negative Regulation Of Cell Development Cardiac Conduction System Development Mesenchymal To Epithelial Transition Canonical Wnt Signaling Pathway Animal Organ Development Stem Cell Differentiation Anatomical Structure Arrangement Mesenchymal Cell Differentiation Positive Regulation Of Embryonic Development Regulation Of Cell Communication Regulation Of Signaling Male Gonad Development Morphogenesis Of An Epithelium Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Central Nervous System Neuron Differentiation Regulation Of Neurogenesis Cell Projection Organization Gonad Development
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