SFRP2

Gene Name		secreted frizzled-related protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Membrane Extracellular Matrix
	Molecular Function	Fibronectin Binding G-protein Coupled Receptor Activity Integrin Binding Metalloenzyme Activator Activity Wnt-protein Binding Wnt-activated Receptor Activity Receptor Agonist Activity Endopeptidase Activator Activity
	Biological Process	Patterning Of Blood Vessels Neural Tube Closure Chondrocyte Development Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Cell-cell Signaling Response To Nutrient Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Endopeptidase Activity Negative Regulation Of Wnt Signaling Pathway Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Cellular Response To Extracellular Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Catenin Import Into Nucleus Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Response To Drug Negative Regulation Of Mesodermal Cell Fate Specification Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of JUN Kinase Activity Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Convergent Extension Involved In Axis Elongation Bone Morphogenesis Sclerotome Development Negative Regulation Of Dermatome Development Hematopoietic Stem Cell Proliferation Cellular Response To X-ray Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Stem Cell Division Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: PAX2 WNT1 WNT4
Entrez ID		6423
HPRD ID		16041
Ensembl ID		ENSG00000145423
Uniprot IDs		B3KSM5 Q96HF1
PDB IDs
Enriched GO Terms of Interacting Partners?		Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Positive Regulation Of Dermatome Development Nephron Morphogenesis Renal Tubule Morphogenesis Paramesonephric Duct Development Renal Tubule Development Kidney Morphogenesis Metanephric Mesenchymal Cell Differentiation Ureteric Bud Development Metanephric Tubule Formation Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Nephron Development Kidney Epithelium Development Mesenchymal Cell Differentiation Involved In Kidney Development Branching Morphogenesis Of An Epithelial Tube Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Morphogenesis Of A Branching Epithelium Renal Vesicle Morphogenesis Morphogenesis Of A Branching Structure Metanephric Mesenchyme Development Mesenchymal To Epithelial Transition Cell Fate Commitment Kidney Development Renal System Development Metanephric Nephron Morphogenesis Epithelial Tube Morphogenesis Urogenital System Development Metanephric Epithelium Development Positive Regulation Of Embryonic Development Metanephros Morphogenesis Tube Morphogenesis Positive Regulation Of Kidney Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Positive Regulation Of Receptor Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Developmental Induction Epithelial Cell Morphogenesis Cell Fate Determination Embryonic Morphogenesis Tissue Morphogenesis T Cell Differentiation In Thymus Tube Development Negative Regulation Of Cell Differentiation Brain Development
Tagcloud ?		act affected b calcium cgamma2 clearly comparing competitive defect defective especially extracellular frizzled influx intracellular lymphocytes modulate phospholipase poorly precise secreted space splenic still stimulation suggested thought understood wnt