SFRP2 and PAX2

Number of citations of the paper that reports this interaction (PMID 14561758)
6

Data Source:
HPRD (in vitro)

		SFRP2	PAX2
Gene Name		secreted frizzled-related protein 2	paired box 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Membrane Extracellular Matrix	Nucleus Lysosome Microtubule Organizing Center Protein-DNA Complex Centriolar Satellite Protein Complex
	Molecular Function	Fibronectin Binding G-protein Coupled Receptor Activity Integrin Binding Metalloenzyme Activator Activity Wnt-protein Binding Wnt-activated Receptor Activity Receptor Agonist Activity Endopeptidase Activator Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Protein Binding Transcription Factor Binding Superoxide-generating NADPH Oxidase Activity Transcription Regulatory Region DNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Patterning Of Blood Vessels Neural Tube Closure Chondrocyte Development Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Cell-cell Signaling Response To Nutrient Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Endopeptidase Activity Negative Regulation Of Wnt Signaling Pathway Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Cellular Response To Extracellular Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Catenin Import Into Nucleus Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Response To Drug Negative Regulation Of Mesodermal Cell Fate Specification Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of JUN Kinase Activity Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Convergent Extension Involved In Axis Elongation Bone Morphogenesis Sclerotome Development Negative Regulation Of Dermatome Development Hematopoietic Stem Cell Proliferation Cellular Response To X-ray Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Stem Cell Division Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Determination Mesonephros Development Neural Tube Closure Optic Cup Morphogenesis Involved In Camera-type Eye Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Retinal Pigment Epithelium Development Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Axonogenesis Mesodermal Cell Fate Specification Aging Visual Perception Glial Cell Differentiation Optic Nerve Development Optic Nerve Morphogenesis Optic Nerve Structural Organization Vestibulocochlear Nerve Formation Pancreas Development Response To Nutrient Levels Regulation Of Metanephros Size Ureter Maturation Pronephric Field Specification Inner Ear Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cytolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Pronephros Development Brain Morphogenesis Stem Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Oxidation-reduction Process Mesenchymal To Epithelial Transition Paramesonephric Duct Development Optic Chiasma Development Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Glucose Stimulus Cellular Response To Epidermal Growth Factor Stimulus Metanephric Mesenchyme Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Mesenchymal Cell Differentiation Mesonephric Tubule Formation Mesonephric Duct Development Nephric Duct Formation Ureter Development Ureter Morphogenesis Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Formation Positive Regulation Of Metanephric Glomerulus Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Reactive Oxygen Species Metabolic Process Cochlea Development Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Optic Nerve Formation
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS			Alzheimer's disease ( 20061627)
Protein-Protein Interactions		3 interactors: PAX2 WNT1 WNT4	11 interactors: BBS1 BBS2 BBS4 BBS7 ID2 MAPK8 MAPK8IP1 PAXIP1 RB1 SFRP2 WT1
Entrez ID		6423	5076
HPRD ID		16041	01330
Ensembl ID		ENSG00000145423	ENSG00000075891
Uniprot IDs		B3KSM5 Q96HF1	Q02962
PDB IDs
Enriched GO Terms of Interacting Partners?		Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Positive Regulation Of Dermatome Development Nephron Morphogenesis Renal Tubule Morphogenesis Paramesonephric Duct Development Renal Tubule Development Kidney Morphogenesis Metanephric Mesenchymal Cell Differentiation Ureteric Bud Development Metanephric Tubule Formation Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Nephron Development Kidney Epithelium Development Mesenchymal Cell Differentiation Involved In Kidney Development Branching Morphogenesis Of An Epithelial Tube Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Morphogenesis Of A Branching Epithelium Renal Vesicle Morphogenesis Morphogenesis Of A Branching Structure Metanephric Mesenchyme Development Mesenchymal To Epithelial Transition Cell Fate Commitment Kidney Development Renal System Development Metanephric Nephron Morphogenesis Epithelial Tube Morphogenesis Urogenital System Development Metanephric Epithelium Development Positive Regulation Of Embryonic Development Metanephros Morphogenesis Tube Morphogenesis Positive Regulation Of Kidney Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Positive Regulation Of Receptor Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Developmental Induction Epithelial Cell Morphogenesis Cell Fate Determination Embryonic Morphogenesis Tissue Morphogenesis T Cell Differentiation In Thymus Tube Development Negative Regulation Of Cell Differentiation Brain Development	Nonmotile Primary Cilium Assembly Anatomical Structure Morphogenesis Tissue Development Tube Development Digestive Tract Development Photoreceptor Cell Maintenance Melanosome Transport Digestive System Development Pigment Granule Transport Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Establishment Of Melanosome Localization Cilium Assembly Melanosome Localization Tube Morphogenesis Visual Perception Sensory Perception Of Light Stimulus Cardiovascular System Development Cilium Organization Regulation Of Gene Expression JUN Phosphorylation Cilium Morphogenesis Heart Development Organ Morphogenesis Positive Regulation Of Growth Heart Morphogenesis Retina Homeostasis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Cellular Pigmentation Anatomical Structure Formation Involved In Morphogenesis Cell Morphogenesis Connective Tissue Development Digestive Tract Morphogenesis Leptin-mediated Signaling Pathway Cell Projection Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Developmental Growth Organ Development Negative Regulation Of Appetite Response To Stimulus Negative Regulation Of Gene Expression Establishment Of Organelle Localization Positive Regulation Of Macrophage Differentiation Cellular Response To Leptin Stimulus Regulation Of Protein Metabolic Process Negative Regulation Of JUN Kinase Activity Regulation Of Microtubule-based Movement Pigmentation Cell Differentiation Epithelial Tube Morphogenesis Striatum Development
Tagcloud ?		act affected b calcium cgamma2 clearly comparing competitive defect defective especially extracellular frizzled influx intracellular lymphocytes modulate phospholipase poorly precise secreted space splenic still stimulation suggested thought understood wnt	agarose childhood concomitantly electrophoretically elucidation embryonal exception films gels heterotransplant hybridized intensifying neoplasm nonrenal nude nylon paired pax8 primer propagated resembling screens segments transferred wilms wt wt1 wts
Tagcloud (Difference) ?		act affected b calcium cgamma2 clearly comparing competitive defect defective especially extracellular frizzled influx intracellular lymphocytes modulate phospholipase poorly precise secreted space splenic still stimulation suggested thought understood wnt	agarose childhood concomitantly electrophoretically elucidation embryonal exception films gels heterotransplant hybridized intensifying neoplasm nonrenal nude nylon paired pax8 primer propagated resembling screens segments transferred wilms wt wt1 wts
Tagcloud (Intersection) ?