SFRP2 and WNT1

Number of citations of the paper that reports this interaction (PMID 10654605)
20

Data Source:
HPRD (in vitro)

		SFRP2	WNT1
Gene Name		secreted frizzled-related protein 2	wingless-type MMTV integration site family, member 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Membrane Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface
	Molecular Function	Fibronectin Binding G-protein Coupled Receptor Activity Integrin Binding Metalloenzyme Activator Activity Wnt-protein Binding Wnt-activated Receptor Activity Receptor Agonist Activity Endopeptidase Activator Activity	Frizzled Binding Cytokine Activity Protein Domain Specific Binding Transcription Regulatory Region DNA Binding Receptor Agonist Activity
	Biological Process	Patterning Of Blood Vessels Neural Tube Closure Chondrocyte Development Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Cell-cell Signaling Response To Nutrient Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Male Gonad Development Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Endopeptidase Activity Negative Regulation Of Wnt Signaling Pathway Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Cellular Response To Extracellular Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Catenin Import Into Nucleus Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Response To Drug Negative Regulation Of Mesodermal Cell Fate Specification Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of JUN Kinase Activity Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Convergent Extension Involved In Axis Elongation Bone Morphogenesis Sclerotome Development Negative Regulation Of Dermatome Development Hematopoietic Stem Cell Proliferation Cellular Response To X-ray Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Stem Cell Division Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation	Embryonic Axis Specification Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Phosphorylation Cell-cell Signaling Myoblast Fusion Positive Regulation Of Cell Proliferation Response To Wounding Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Cell-substrate Adhesion Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Diencephalon Development Central Nervous System Morphogenesis Cerebellum Formation Forebrain Anterior/posterior Pattern Specification Midbrain-hindbrain Boundary Maturation During Brain Development Negative Regulation Of Cell-cell Adhesion Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Midbrain Development Organ Regeneration T Cell Differentiation In Thymus Inner Ear Morphogenesis Signal Transduction In Response To DNA Damage Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Neuron Fate Determination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Spemann Organizer Formation Canonical Wnt Signaling Pathway Bone Development Positive Regulation Of Dermatome Development Hepatocyte Differentiation Cellular Response To Peptide Hormone Stimulus Hematopoietic Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Aging Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation negative regulation of TCF-dependent signaling by WNT ligand antagonists XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt GPCR ligand binding Metabolic disorders of biological oxidation enzymes WNT ligand biogenesis and trafficking beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Class B/2 (Secretin family receptors) PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PAX2 WNT1 WNT4	9 interactors: FZD8 FZD9 LRP5 LRP6 PORCN RYK SFRP1 SFRP2 WNT3A
Entrez ID		6423	7471
HPRD ID		16041	01276
Ensembl ID		ENSG00000145423
Uniprot IDs		B3KSM5 Q96HF1	P04628
PDB IDs
Enriched GO Terms of Interacting Partners?		Branching Involved In Ureteric Bud Morphogenesis Ureteric Bud Morphogenesis Positive Regulation Of Dermatome Development Nephron Morphogenesis Renal Tubule Morphogenesis Paramesonephric Duct Development Renal Tubule Development Kidney Morphogenesis Metanephric Mesenchymal Cell Differentiation Ureteric Bud Development Metanephric Tubule Formation Mesonephric Tubule Development Mesonephric Epithelium Development Mesonephros Development Nephron Development Kidney Epithelium Development Mesenchymal Cell Differentiation Involved In Kidney Development Branching Morphogenesis Of An Epithelial Tube Cell Differentiation Involved In Metanephros Development Metanephric Tubule Morphogenesis Morphogenesis Of A Branching Epithelium Renal Vesicle Morphogenesis Morphogenesis Of A Branching Structure Metanephric Mesenchyme Development Mesenchymal To Epithelial Transition Cell Fate Commitment Kidney Development Renal System Development Metanephric Nephron Morphogenesis Epithelial Tube Morphogenesis Urogenital System Development Metanephric Epithelium Development Positive Regulation Of Embryonic Development Metanephros Morphogenesis Tube Morphogenesis Positive Regulation Of Kidney Development Cell Differentiation Involved In Kidney Development Metanephric Nephron Development Positive Regulation Of Receptor Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Developmental Induction Epithelial Cell Morphogenesis Cell Fate Determination Embryonic Morphogenesis Tissue Morphogenesis T Cell Differentiation In Thymus Tube Development Negative Regulation Of Cell Differentiation Brain Development	Wnt Signaling Pathway Canonical Wnt Signaling Pathway Axis Elongation Involved In Somitogenesis Non-canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Axis Elongation Regulation Of Fat Cell Differentiation Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Cell Surface Receptor Signaling Pathway Convergent Extension Anterior/posterior Pattern Specification Somitogenesis Stem Cell Proliferation Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Somite Development Regulation Of Wnt Signaling Pathway Positive Regulation Of Signal Transduction Post-anal Tail Morphogenesis Regulation Of Phosphorylation Immune System Development Regulation Of Embryonic Development Segmentation Regulation Of Protein Kinase Activity Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Regulation Of Kinase Activity Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Regulation Of Phosphorus Metabolic Process Epithelial Tube Morphogenesis Negative Regulation Of Protein Serine/threonine Kinase Activity Developmental Growth Involved In Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Stem Cell Differentiation Tube Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Axis Elongation Pattern Specification Process Regulation Of Organ Morphogenesis Regulation Of Bone Remodeling Morphogenesis Of An Epithelium Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Organ Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Ossification Regulation Of Protein Phosphorylation Mesenchyme Development Neural Crest Formation
Tagcloud ?		act affected b calcium cgamma2 clearly comparing competitive defect defective especially extracellular frizzled influx intracellular lymphocytes modulate phospholipase poorly precise secreted space splenic still stimulation suggested thought understood wnt	access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would
Tagcloud (Difference) ?		act affected b calcium cgamma2 clearly comparing competitive defect defective especially extracellular frizzled influx intracellular lymphocytes modulate phospholipase poorly precise secreted space splenic still stimulation suggested thought understood wnt	access acid breaks chromosome cloning embryonic experiments inducible karyotypes late lines morphologies morphology neurogenesis observing p19 placed produced responsive resulting retinoic see sequences transcribed undifferentiated useful variety wide would
Tagcloud (Intersection) ?