SFRP2 and WNT4

Number of citations of the paper that reports this interaction (PubMedID 9853965)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SFRP2	WNT4
Description		secreted frizzled related protein 2	Wnt family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Fibronectin Binding Integrin Binding Enzyme Activator Activity Wnt-protein Binding Receptor Ligand Activity Endopeptidase Activator Activity	Transcription Corepressor Activity Signaling Receptor Binding Frizzled Binding Cytokine Activity Receptor Ligand Activity
	Biological Process	Regulation Of Cell Growth Branching Involved In Blood Vessel Morphogenesis Somitogenesis Neural Tube Closure Chondrocyte Development Outflow Tract Morphogenesis Cardiac Left Ventricle Morphogenesis Apoptotic Process Cell-cell Signaling Mesodermal Cell Fate Specification Response To Nutrient Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Xenobiotic Stimulus Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Wnt Signaling Pathway Neural Tube Development Regulation Of Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Collagen Fibril Organization Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Cell Adhesion Mediated By Integrin Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Regulation Of Cell Population Proliferation Negative Regulation Of Mesodermal Cell Fate Specification Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Development Of Primary Male Sexual Characteristics Digestive Tract Morphogenesis Stem Cell Fate Specification Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Convergent Extension Involved In Axis Elongation Canonical Wnt Signaling Pathway Sclerotome Development Negative Regulation Of Dermatome Development Hematopoietic Stem Cell Proliferation Cellular Response To X-ray Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Wnt Signaling Pathway Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Midbrain Dopaminergic Neuron Differentiation Regulation Of Stem Cell Division	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Gamete Generation Sex Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Wnt Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process T Cell Differentiation In Thymus Immature T Cell Proliferation In Thymus Tube Morphogenesis Non-canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Hormone Metabolic Process Positive Regulation Of MAPK Cascade Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Ras Protein Signal Transduction Oocyte Development Branching Morphogenesis Of An Epithelial Tube Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Sertoli Cell Differentiation Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Kidney Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Nephron Development Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Mesonephric Tubule Development Metanephric Tubule Formation Metanephric Nephron Development Metanephric Nephron Morphogenesis Apoptotic Signaling Pathway Meiotic Nuclear Division Pericyte Cell Differentiation Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists	TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists PCP/CE pathway PCP/CE pathway Nephron development
Drugs
Diseases			46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Facial morphology ( 31763980) Macular thickness ( 30535121) Nose morphology ( 29921221 33593615) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes (age of onset) ( 28060188)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 25990418) Daytime sleep phenotypes ( 27126917) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Dupuytren's disease ( 21732829 28886342) Endometriosis ( 20601957 23472165 23104006 28333195 28537267) Epithelial ovarian cancer ( 25581431) Extremely high intelligence ( 29520040) Gestational age at birth (maternal effect) ( 28877031) Gynecologic disease ( 31488892) Gynecologic disease (multivariate analysis) ( 31488892) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Iron status biomarkers (ferritin levels) ( 33536631) Lumbar spine bone mineral density ( 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Pelvic organ prolapse ( 32184442) Right-sided colonic diverticulosis ( 31089239) Spine bone size ( 31053729) Systolic blood pressure ( 30224653) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 34074324) Uterine fibroids ( 31649266 31488892 31249589 30194396) Uterine fibroids (MTAG) ( 31488892) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: BMPR1A BUB1 CDH1 CTNNA1 DBNDD2 DCC EEF1G MLH3 PAX2 PFKM RAD54B SFRP5 SMAD4 WNT1 WNT4	8 interacting genes: APP FZD6 LGALS3BP P2RX4 PORCN SFRP1 SFRP2 TMEM80
Entrez ID		6423	54361
HPRD ID		16041	04601
Ensembl ID		ENSG00000145423	ENSG00000162552
Uniprot IDs		A0A140VJU3 B3KSM5 Q96HF1	P56705
PDB IDs
Enriched GO Terms of Interacting Partners?		Branching Involved In Ureteric Bud Morphogenesis Tube Morphogenesis Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Cell Differentiation Positive Regulation Of Dermatome Development Negative Regulation Of Neurogenesis Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Nervous System Development Regulation Of Multicellular Organismal Development Cellular Response To Indole-3-methanol Morphogenesis Of A Branching Epithelium Metanephric Tubule Formation Metanephric Mesenchymal Cell Differentiation Morphogenesis Of A Branching Structure Response To Indole-3-methanol Mesendoderm Development Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Cell Differentiation Tissue Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Flotillin Complex Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Kidney Development Axis Specification Neuron Projection Development Gamma-catenin Binding Mesonephros Development Animal Organ Morphogenesis Regionalization Gland Development Negative Regulation Of Cell Development Cardiac Conduction System Development Mesenchymal To Epithelial Transition Canonical Wnt Signaling Pathway Animal Organ Development Stem Cell Differentiation Anatomical Structure Arrangement Mesenchymal Cell Differentiation Positive Regulation Of Embryonic Development Regulation Of Cell Communication Regulation Of Signaling Male Gonad Development Morphogenesis Of An Epithelium Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Central Nervous System Neuron Differentiation Regulation Of Neurogenesis Cell Projection Organization Gonad Development	Wnt-protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Non-canonical Wnt Signaling Pathway Development Of Primary Male Sexual Characteristics Regulation Of Canonical Wnt Signaling Pathway Convergent Extension Involved In Axis Elongation Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Development Of Primary Sexual Characteristics Neural Tube Closure Regulation Of Wnt Signaling Pathway Cellular Response To X-ray Tube Closure Canonical Wnt Signaling Pathway Regulation Of Dopaminergic Neuron Differentiation Convergent Extension Tube Formation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Digestive Tract Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Response To X-ray Regulation Of Neuron Differentiation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Projection Organization Positive Regulation Of Nitric Oxide Metabolic Process Neural Tube Development Negative Regulation Of Epithelial To Mesenchymal Transition Somitogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Segmentation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Signal Transduction Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Fat Cell Differentiation Convergent Extension Involved In Somitogenesis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?