KNL1 and BUB1B

Number of citations of the paper that reports this interaction (PubMedID 20220147)
60

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		KNL1	BUB1B
Description		kinetochore scaffold 1	BUB1 mitotic checkpoint serine/threonine kinase B
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body Knl1/Spc105 Complex	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Anaphase-promoting Complex Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Checkpoint Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Acrosome Assembly Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Homologous Chromosome Orientation In Meiotic Metaphase I Protein Localization To Kinetochore Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Meiosis I Spindle Assembly Checkpoint	Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Sister Chromatid Segregation Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Chronic lymphocytic leukemia ( 24292274 28165464)
Interacting Genes		6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK	31 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DHX8 DNMBP FBXO7 HDAC1 HOPX KNL1 MAP3K4 PELI1 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E RIPK3 SNCG TP73 TRIP13
Entrez ID		57082	701
HPRD ID		10634	04176
Ensembl ID		ENSG00000137812	ENSG00000156970
Uniprot IDs		Q8NG31	O60566
PDB IDs		3SI5 4A1G 4NF9 4NFA 6CZO 8PPR 8Q5H	2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Kinetochore Chromosome, Centromeric Region Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome Segregation Cell Division Negative Regulation Of Mitotic Nuclear Division Meiotic Sister Chromatid Cohesion, Centromeric MIS12/MIND Type Complex Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Protein Serine Kinase Activity Meiotic Sister Chromatid Cohesion Regulation Of Sister Chromatid Segregation Protein Serine/threonine Kinase Activity Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Regulation Of Nuclear Division Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinase Activity Organelle Organization Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromosome Attachment Of Spindle Microtubules To Kinetochore Regulation Of Chromosome Organization Protein Localization To Chromosome, Centromeric Region Sister Chromatid Cohesion Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Meiotic Spindle Midzone Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Repair Of Mitotic Kinetochore Microtubule Attachment Defect Meiotic Spindle Checkpoint Signaling Nucleus Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle	Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Separation Protein Phosphatase Type 2A Complex Protein Phosphatase Activator Activity Cytosol Regulation Of Mitotic Nuclear Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Clathrin Adaptor Complex Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nuclear Division Protein Phosphatase Regulator Activity Regulation Of Cell Cycle Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Membrane Coat Mitotic Spindle Assembly Checkpoint Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome, Centromeric Region Negative Regulation Of Mitotic Nuclear Division Regulation Of Reproductive Process Cell Division Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Chromosome Organization Chromosome Spindle Positive Regulation Of Mitotic Metaphase/anaphase Transition Ubiquitin-dependent Protein Catabolic Process Protein Branched Polyubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Cell Cycle Process Protein Catabolic Process Kinetochore Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Chromosome Organization Centrosome Mitotic Checkpoint Complex Proteolysis Involved In Protein Catabolic Process Regulation Of Meiotic Nuclear Division Regulation Of Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
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