CASC5 and MIS12

Number of citations of the paper that reports this interaction (PMID 15502821)
80

Data Source:
HPRD (in vivo, in vitro)

		CASC5	MIS12
Gene Name		cancer susceptibility candidate 5	MIS12 kinetochore complex component
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome	MIS12/MIND Type Complex Nucleus Cytosol
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Acrosome Assembly Nucleosome Assembly Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Negative Regulation Of Phosphatase Activity CENP-A Containing Nucleosome Assembly Protein Localization To Kinetochore Cell Division Spindle Assembly Checkpoint	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division Kinetochore Assembly
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK	10 interactors: CASC5 CBX3 CBX5 DSN1 HSP90AA1 NDC80 NSL1 PMF1 SUGT1 ZWINT
Entrez ID		57082	79003
HPRD ID		10634	12379
Ensembl ID		ENSG00000137812	ENSG00000167842
Uniprot IDs		Q8NG31	A8K1M4 Q9H081
PDB IDs		3SI5 4A1G
Enriched GO Terms of Interacting Partners?		Cell Division Cell Cycle Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Chromosome Segregation Mitotic Cell Cycle Process Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Cell Cycle Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Mitotic Nuclear Division Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Cell Cycle Process Negative Regulation Of Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Regulation Of Cell Division Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process Organelle Organization Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Glycogen Catabolic Process Protein Localization To Kinetochore	Mitotic Nuclear Division Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Segregation Cell Cycle Process Cell Cycle Cell Division Organelle Organization Attachment Of Spindle Microtubules To Kinetochore Chromosome Organization Microtubule Anchoring Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Maintenance Of Protein Location In Cell Protein Import Into Mitochondrial Outer Membrane Chromatin Modification Maintenance Of Protein Location Maintenance Of Location In Cell Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Remodeling Chromatin Organization Protein Localization To Kinetochore Cell Cycle Checkpoint Protein Localization To Chromosome, Centromeric Region Histone H4-K5 Acetylation Histone H4-K8 Acetylation Chaperone-mediated Protein Complex Assembly Histone H4-K16 Acetylation Acrosome Assembly
Tagcloud ?		13ra2 a12 antigen antigens bage chemo contributing ct ctage1 ddx43 gbm glioblastoma glioma gp100 ihc immunotherapy impressively institute inversely mage mgmt multiforme neoplasia primers rembrandt repository tdrd1 testis verified	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?		13ra2 a12 antigen antigens bage chemo contributing ct ctage1 ddx43 gbm glioblastoma glioma gp100 ihc immunotherapy impressively institute inversely mage mgmt multiforme neoplasia primers rembrandt repository tdrd1 testis verified	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?