KNL1

Description		kinetochore scaffold 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body Knl1/Spc105 Complex
	Molecular Function	Protein Binding Microtubule Binding
	Biological Process	Mitotic Sister Chromatid Segregation Acrosome Assembly Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Homologous Chromosome Orientation In Meiotic Metaphase I Protein Localization To Kinetochore Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Meiosis I Spindle Assembly Checkpoint
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Novel Interacting Genes		1 novel interacting genes: PAK6
Interacting Genes		6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK
Entrez ID		57082
HPRD ID		10634
Ensembl ID		ENSG00000137812
Uniprot IDs		Q8NG31
PDB IDs		3SI5 4A1G 4NF9 4NFA 6CZO 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Kinetochore Chromosome, Centromeric Region Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome Segregation Cell Division Negative Regulation Of Mitotic Nuclear Division Meiotic Sister Chromatid Cohesion, Centromeric MIS12/MIND Type Complex Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Protein Serine Kinase Activity Meiotic Sister Chromatid Cohesion Regulation Of Sister Chromatid Segregation Protein Serine/threonine Kinase Activity Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Regulation Of Nuclear Division Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinase Activity Organelle Organization Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromosome Attachment Of Spindle Microtubules To Kinetochore Regulation Of Chromosome Organization Protein Localization To Chromosome, Centromeric Region Sister Chromatid Cohesion Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Meiotic Spindle Midzone Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Repair Of Mitotic Kinetochore Microtubule Attachment Defect Meiotic Spindle Checkpoint Signaling Nucleus Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle
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