KNL1 and DSN1

Number of citations of the paper that reports this interaction (PubMedID 15502821)
0

Data Source:
HPRD (in vivo)

		KNL1	DSN1
Description		kinetochore scaffold 1	DSN1 component of MIS12 kinetochore complex
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Acrosomal Vesicle Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Body Knl1/Spc105 Complex	MIS12/MIND Type Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Outer Kinetochore Fibrillar Center Extracellular Region Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Nuclear Body Azurophil Granule Lumen
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Acrosome Assembly Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Homologous Chromosome Orientation In Meiotic Metaphase I Protein Localization To Kinetochore Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Meiosis I Spindle Assembly Checkpoint	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Skeletal Muscle Satellite Cell Proliferation Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Neutrophil degranulation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Anxiety and stress-related disorders ( 31116379) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Factor VII activity ( 30642921) Hallux valgus ( 32131869)
Interacting Genes		6 interacting genes: BUB1 BUB1B DSN1 MIS12 PPP1CA TTK	12 interacting genes: AIMP2 APP CBX3 CBX5 HGS KNL1 MIS12 NSL1 PIK3R3 PMF1 SUGT1 ZWINT
Entrez ID		57082	79980
HPRD ID		10634	16455
Ensembl ID		ENSG00000137812	ENSG00000149636
Uniprot IDs		Q8NG31	A8K3X3 Q9H410
PDB IDs		3SI5 4A1G 4NF9 4NFA 6CZO 8PPR 8Q5H	5LSI 5LSJ 5LSK 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Kinetochore Chromosome, Centromeric Region Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Chromosome Segregation Cell Division Negative Regulation Of Mitotic Nuclear Division Meiotic Sister Chromatid Cohesion, Centromeric MIS12/MIND Type Complex Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Protein Serine Kinase Activity Meiotic Sister Chromatid Cohesion Regulation Of Sister Chromatid Segregation Protein Serine/threonine Kinase Activity Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Regulation Of Nuclear Division Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Kinase Activity Organelle Organization Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Chromosome Attachment Of Spindle Microtubules To Kinetochore Regulation Of Chromosome Organization Protein Localization To Chromosome, Centromeric Region Sister Chromatid Cohesion Negative Regulation Of Cell Cycle Process Nuclear Chromosome Segregation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Meiotic Spindle Midzone Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Repair Of Mitotic Kinetochore Microtubule Attachment Defect Meiotic Spindle Checkpoint Signaling Nucleus Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle	Outer Kinetochore Kinetochore Chromosome, Centromeric Region MIS12/MIND Type Complex Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Chromosome Segregation Nuclear Chromosome Segregation Knl1/Spc105 Complex Regulation Of Meiosis I Spindle Assembly Checkpoint Homologous Chromosome Orientation In Meiotic Metaphase I Chromosome Organization Chromosome Regulation Of Meiosis I Cell Division Kinetochore Assembly Kinetochore Organization Spindle Pole Pericentric Heterochromatin Regulation Of Meiotic Nuclear Division Cytosol Site Of DNA Damage Heterochromatin Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Meiosis I Spindle Assembly Checkpoint Epigenetic Regulation Of Gene Expression Regulation Of Mitotic Sister Chromatid Separation Regulation Of Meiotic Cell Cycle Positive Regulation Of Neuron Apoptotic Process Organelle Assembly Regulation Of Chromosome Separation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Chromosome Localization Nucleus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization
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