TCP1 and TUBA4A

Number of citations of the paper that reports this interaction (PubMedID 9885248)
47

Data Source:
HPRD (in vivo)

		TCP1	TUBA4A
Description		t-complex 1	tubulin alpha 4a
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Heterochromatin Acrosomal Vesicle Zona Pellucida Receptor Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome Intracellular Protein-containing Complex	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Extracellular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Nucleotide Binding Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Enzyme Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization ScaRNA Localization To Cajal Body Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate
Diseases
GWAS			Platelet distribution width ( 27863252 32888494) Severe autoimmune type 2 diabetes ( 34737425)
Interacting Genes		18 interacting genes: ANXA1 CBFA2T2 CCT5 CCT7 CDC20 CEBPA DUX4 FANCA OGT PDCL PTEN SH3BP4 SLC26A4-AS1 SUMO2 TUBA4A TUBA8 VRK2 YWHAQ	53 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UBC UCHL5 VAV1 VDAC1 YWHAG ZAP70
Entrez ID		6950	7277
HPRD ID		01748	01851
Ensembl ID		ENSG00000120438	ENSG00000127824
Uniprot IDs		E7EQR6 P17987	P68366
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex Binding Regulation Of Proteolysis Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Ligase Activator Activity Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Negative Regulation Of Cell Cycle Binding Of Sperm To Zona Pellucida Regulation Of Protein Catabolic Process ATP-dependent Protein Folding Chaperone Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Heterotrimeric G-protein Complex Assembly Negative Regulation Of Synaptic Vesicle Clustering Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Sperm-egg Recognition Microtubule Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Organelle Organization Cytoplasm Protein Domain Specific Binding Protein Localization To Lysosome Cell-cell Recognition Protein Folding Chaperone Regulation Of Cellular Component Organization Regulation Of Chromosome Organization Response To Vitamin B2 C/EBP Complex	Alpha-tubulin Binding Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Microtubule Cytosol Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Regulation Of Cellular Component Organization Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Protein Localization Plasma Membrane Tubulin Binding Regulation Of Protein Catabolic Process Dendrite Positive Regulation Of Intracellular Signal Transduction Cell Migration Regulation Of Cell Communication Regulation Of Signaling Regulation Of Organelle Organization Cytoskeleton Regulation Of Multicellular Organismal Process Microtubule Binding Tau Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Signal Transduction Cell Motility Negative Regulation Of Catabolic Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Bounded Cell Projection Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Leukocyte Migration Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To L-glutamate Inclusion Body Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Tubulin Complex Assembly
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