TCP1 and CCT7

Number of citations of the paper that reports this interaction (PubMedID 9250675)
20

Data Source:
HPRD (in vitro)

		TCP1	CCT7
Description		t-complex 1	chaperonin containing TCP1 subunit 7
Image
GO Annotations	Cellular Component	Pericentriolar Material Heterochromatin Acrosomal Vesicle Zona Pellucida Receptor Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome Intracellular Protein-containing Complex	Cytoplasm Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Exosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization ScaRNA Localization To Cajal Body Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS			General cognitive ability ( 29844566)
Interacting Genes		18 interacting genes: ANXA1 CBFA2T2 CCT5 CCT7 CDC20 CEBPA DUX4 FANCA OGT PDCL PTEN SH3BP4 SLC26A4-AS1 SUMO2 TUBA4A TUBA8 VRK2 YWHAQ	26 interacting genes: ANXA1 ANXA7 APP ATP5F1C BTG3 CDKN1A CEBPA CEBPE CRMP1 DNM2 EEF1G KAT5 KRAS LINC01554 MED31 NHLH1 NKX3-1 OGT PRPF40A RAP1B RCC1 SUMO4 TCP1 VHL WBP2 ZNRD2
Entrez ID		6950	10574
HPRD ID		01748	06896
Ensembl ID		ENSG00000120438	ENSG00000135624
Uniprot IDs		E7EQR6 P17987	Q99832
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex Binding Regulation Of Proteolysis Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Ligase Activator Activity Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Negative Regulation Of Cell Cycle Binding Of Sperm To Zona Pellucida Regulation Of Protein Catabolic Process ATP-dependent Protein Folding Chaperone Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Heterotrimeric G-protein Complex Assembly Negative Regulation Of Synaptic Vesicle Clustering Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Sperm-egg Recognition Microtubule Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Organelle Organization Cytoplasm Protein Domain Specific Binding Protein Localization To Lysosome Cell-cell Recognition Protein Folding Chaperone Regulation Of Cellular Component Organization Regulation Of Chromosome Organization Response To Vitamin B2 C/EBP Complex	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Binding Response To Steroid Hormone Response To Lipid Regulation Of Cell Cycle Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Binding Intracellular Signal Transduction Protein-containing Complex Binding Negative Regulation Of Gene Expression Regulation Of Programmed Cell Death Positive Regulation Of Cell Activation Regulation Of Gene Expression Response To Hormone Positive Regulation Of Gene Expression Response To Ketone Chromatin DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Developmental Process Phagocytosis Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Cellular Developmental Process Regulation Of Cell Population Proliferation Histone Acetyltransferase Complex Regulation Of Cell Junction Assembly Molecular Function Activator Activity Developmental Process Regulation Of Long-term Neuronal Synaptic Plasticity Phagocytic Cup Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Amyloid Fibril Formation Granulocyte Differentiation Chromatin Positive Regulation Of Mitotic Cell Cycle Response To Glucocorticoid Autophagy Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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