TCP1 and CBFA2T2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		TCP1	CBFA2T2
Description		t-complex 1	CBFA2/RUNX1 partner transcriptional co-repressor 2
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Heterochromatin Acrosomal Vesicle Zona Pellucida Receptor Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome Intracellular Protein-containing Complex	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization ScaRNA Localization To Cajal Body Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Epithelial Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Intestinal Epithelial Cell Differentiation
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Specification of primordial germ cells
Drugs
Diseases
GWAS			Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Triglyceride levels ( 32203549)
Interacting Genes		18 interacting genes: ANXA1 CBFA2T2 CCT5 CCT7 CDC20 CEBPA DUX4 FANCA OGT PDCL PTEN SH3BP4 SLC26A4-AS1 SUMO2 TUBA4A TUBA8 VRK2 YWHAQ	34 interacting genes: APP ATN1 ATXN1L BAG4 CBFA2T3 CBFB CEP83 FBXL19 GTF2E1 ID3 KIFC3 KRTAP13-2 LBP MAGEA6 MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 NTAQ1 PDP1 PEX14 PHAF1 PRDM6 RERE RUNX1 SIKE1 SIN3A SORBS3 TAL2 TCF4 TCP1 ZC2HC1A ZNF652
Entrez ID		6950	9139
HPRD ID		01748	04721
Ensembl ID		ENSG00000120438	ENSG00000078699
Uniprot IDs		E7EQR6 P17987	O43439
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex Binding Regulation Of Proteolysis Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Ligase Activator Activity Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Negative Regulation Of Cell Cycle Binding Of Sperm To Zona Pellucida Regulation Of Protein Catabolic Process ATP-dependent Protein Folding Chaperone Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Heterotrimeric G-protein Complex Assembly Negative Regulation Of Synaptic Vesicle Clustering Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Sperm-egg Recognition Microtubule Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Organelle Organization Cytoplasm Protein Domain Specific Binding Protein Localization To Lysosome Cell-cell Recognition Protein Folding Chaperone Regulation Of Cellular Component Organization Regulation Of Chromosome Organization Response To Vitamin B2 C/EBP Complex	Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Core-binding Factor Complex Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Transcription Regulator Inhibitor Activity Nucleus Histone Deacetylase Complex Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Protein Binding Transcription Repressor Complex Chromatin Binding Protein Dimerization Activity Regulation Of ATP Metabolic Process DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Regulation Of Purine Nucleotide Metabolic Process Response To Catecholamine Neuron Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of Glycolytic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of ATP Metabolic Process Amyloid-beta Complex
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