TCP1 and FANCA

Number of citations: 0 (PubMedID 14499622)
Data Source: BioGRID (two hybrid)

		TCP1	FANCA
Name		t-complex 1	FA complementation group A
Structure
GO Annotations	Cellular Component	Pericentriolar Material Heterochromatin Acrosomal Vesicle Zona Pellucida Receptor Complex Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome Intracellular Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein Folding Chaperone Unfolded Protein Binding ATP-dependent Protein Folding Chaperone	Protein Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization ScaRNA Localization To Cajal Body Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	DNA Repair DNA Damage Response Male Meiotic Nuclear Division Male Gonad Development Female Gonad Development Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Regulation Of Inflammatory Response Protein-containing Complex Assembly Regulation Of Germ Cell Proliferation Regulation Of CD40 Signaling Pathway
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Fanconi Anemia Pathway PKR-mediated signaling
Diseases		None	Fanconi anemia
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hair morphology traits ( 30166351 ) Hemoglobin levels ( 32327693 ) Homocysteine levels ( 23824729 ) Intraocular pressure ( 29617998 29785010 30054594 31959993 ) Low tan response ( 29739929 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Red vs. brown/black hair color ( 30531825 ) Rosacea symptom severity ( 29771307 ) Skin pigmentation traits ( 30166351 )
Interacting Genes		18 interacting genes: ANXA1 CBFA2T2 CCT5 CCT7 CDC20 CEBPA DUX4 FANCA OGT PDCL PTEN SH3BP4 SLC26A4-AS1 SUMO2 TUBA4A TUBA8 VRK2 YWHAQ	47 interacting genes: AKT1 ALDOA ATP5F1B ATR AURKA AZIN1 BRCA1 CAPN1 CCT3 CD79A CDK1 CENPE DAXX DDX39B DNAJB1 DUS4L ENO1 FANCC FANCE FANCF FANCG GNB2 HES1 HPRT1 IFIT3 IKBKB KRT1 LIPG MKNK1 MX1 NAMPT NUB1 PRKAA1 PRPF31 PSMA5 RPL18 SGK1 SMARCA4 SMARCC1 SMARCD3 SNX5 SPTAN1 TAF10 TCERG1 TCP1 TPT1 ZNF24
Entrez ID		6950	2175
HPRD ID		01748	06186
Ensembl ID		ENSG00000120438	ENSG00000187741
Uniprot IDs		E7EQR6 P17987	O15360 Q0VAP4
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
GO Terms Enriched among Interactors		Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Anaphase-promoting Complex Binding Regulation Of Proteolysis Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Ligase Activator Activity Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Microtubule Negative Regulation Of Cell Cycle Binding Of Sperm To Zona Pellucida Regulation Of Protein Catabolic Process ATP-dependent Protein Folding Chaperone Positive Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Protein-containing Complex Metaphase/anaphase Transition Of Meiosis I RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Heterotrimeric G-protein Complex Assembly Negative Regulation Of Synaptic Vesicle Clustering Organelle Envelope Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Sperm-egg Recognition Microtubule Cytoskeleton Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Organelle Organization Cytoplasm Protein Domain Specific Binding Protein Localization To Lysosome Cell-cell Recognition Protein Folding Chaperone Regulation Of Cellular Component Organization Regulation Of Chromosome Organization Response To Vitamin B2 C/EBP Complex	Positive Regulation Of DNA Metabolic Process Nucleus Protein-containing Complex Organization Interstrand Cross-link Repair Fanconi Anaemia Nuclear Complex Regulation Of Mitotic Cell Cycle Phase Transition Cytosol Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Cytoplasm Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Stress Nucleoplasm Regulation Of Cell Cycle Phase Transition Protein-containing Complex Assembly Protein Serine Kinase Activity Positive Regulation Of Macromolecule Metabolic Process DNA Strand Resection Involved In Replication Fork Processing NpBAF Complex Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Chromatin Remodeling Identical Protein Binding Regulation Of G2/M Transition Of Mitotic Cell Cycle NBAF Complex Regulation Of Sister Chromatid Segregation Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity ATP Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle G2/M Phase Transition RNA Polymerase Binding Response To Tumor Necrosis Factor Regulation Of Signal Transduction By P53 Class Mediator Nucleosome Disassembly Positive Regulation Of Mitotic Cell Cycle Protein-DNA Complex Disassembly Regulation Of Chromosome Segregation Positive Regulation Of Telomere Maintenance Via Telomerase Nucleotide Binding Positive Regulation Of Biosynthetic Process Regulation Of DNA Repair Protein K6-linked Ubiquitination Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Phosphate-containing Compound Metabolic Process Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of Protein Localization To Nucleus