TCP1 and TUBA8

Number of citations of the paper that reports this interaction (PMID 9885248)
11

Data Source:
HPRD (in vivo)

		TCP1	TUBA8
Gene Name		t-complex 1	tubulin, alpha 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Pericentriolar Material Acrosomal Vesicle Zona Pellucida Receptor Complex Nuclear Heterochromatin Golgi Apparatus Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Vesicular Exosome	Cytoplasm Microtubule
	Molecular Function	Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Unfolded Protein Binding	GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding
	Biological Process	Protein Folding Tubulin Complex Assembly Binding Of Sperm To Zona Pellucida Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport Regulation Of Macrophage Apoptotic Process	Microtubule-based Process Protein Polymerization
Pathways		Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs			Epothilone D Epothilone B
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CBFA2T2 CCT5 CCT7 CDC20 FANCA HSPA8 PDCL SH3BP4 TUBA4A TUBA8 VRK2 YWHAQ	5 interactors: GRM7 MYC PXN SIAH1 TCP1
Entrez ID		6950	51807
HPRD ID		01748	05763
Ensembl ID		ENSG00000120438	ENSG00000183785
Uniprot IDs		E7EQR6 F5H282 P17987	Q9NY65
PDB IDs
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Protein Folding Toxin Transport Regulation Of Cellular Component Organization Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Negative Regulation Of Fibril Organization Heterotrimeric G-protein Complex Assembly Protein Polymerization Protein Complex Assembly Regulation Of Fibril Organization Regulation Of Interleukin-1-mediated Signaling Pathway Cell Recognition Single Fertilization Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Refolding Clathrin Coat Disassembly Fertilization Activation Of Anaphase-promoting Complex Activity Positive Regulation Of Synaptic Plasticity Vesicle-mediated Transport	Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Translocation Of Peptides Or Proteins Into Host Cell Cytoplasm Transforming Growth Factor Beta Receptor Signaling Pathway Fibroblast Apoptotic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Branching Morphogenesis Of An Epithelial Tube Morphogenesis Of A Branching Epithelium Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Morphogenesis Of A Branching Structure Conditioned Taste Aversion Regulation Of Signaling Negative Regulation Of Monocyte Differentiation Negative Regulation Of Glutamate Secretion Positive Regulation Of Cell Proliferation Involved In Kidney Development Cellular Protein Complex Assembly Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Adenylate Cyclase-inhibiting G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Macrophage Apoptotic Process Epithelial Tube Morphogenesis Regulation Of Cell Death Regulation Of Glutamate Secretion Tubulin Complex Assembly Regulation Of Monocyte Differentiation Signal Complex Assembly Short-term Memory Tube Morphogenesis Regulation Of Intracellular Signal Transduction G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of Telomere Maintenance Positive Regulation Of DNA Biosynthetic Process Morphogenesis Of An Epithelium Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Protein Destabilization Growth Hormone Receptor Signaling Pathway Oxygen Transport Cellular Response To Growth Hormone Stimulus Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Focal Adhesion Assembly Regulation Of MAPK Cascade Positive Regulation Of Cell Death Negative Regulation Of CAMP Metabolic Process Cellular Macromolecular Complex Assembly Tissue Morphogenesis
Tagcloud ?		associates cct chaperonin combinatorial comprised concerning concordant constituting counting factorial fixed implies infer inter micro microcomplexes orientation partners possibilities predictions probable ring subsets subunit subunits symmetry topology torodial wts	abnormality acetyltransferase anatomical atypical autosomal autozygosity believed correct cytoskeletal doublecortin elongator generalized germline hypoplasia identities lis1 lissencephaly mapping microtubule neurodevelopmental neuron optic pmgoh polymicrogyria recessive recognizable tuba1a tubulin underscored
Tagcloud (Difference) ?		associates cct chaperonin combinatorial comprised concerning concordant constituting counting factorial fixed implies infer inter micro microcomplexes orientation partners possibilities predictions probable ring subsets subunit subunits symmetry topology torodial wts	abnormality acetyltransferase anatomical atypical autosomal autozygosity believed correct cytoskeletal doublecortin elongator generalized germline hypoplasia identities lis1 lissencephaly mapping microtubule neurodevelopmental neuron optic pmgoh polymicrogyria recessive recognizable tuba1a tubulin underscored
Tagcloud (Intersection) ?